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CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3.
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Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.
J Biol Chem. 2006 Jun 30;281(26):18059-68. doi: 10.1074/jbc.M601903200. Epub 2006 Apr 24.
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Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.
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Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Mol Cell Proteomics. 2011 Apr;10(4):M110.002642. doi: 10.1074/mcp.M110.002642. Epub 2011 Jan 31.
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Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.
Am J Physiol Renal Physiol. 2010 Jul;299(1):F63-76. doi: 10.1152/ajprenal.00105.2010. Epub 2010 Apr 28.
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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12.
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MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.
Cell Rep. 2013 May 30;3(5):1553-66. doi: 10.1016/j.celrep.2013.03.038. Epub 2013 Apr 25.

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How CBX proteins regulate normal and leukemic blood cells.
FEBS Lett. 2024 Nov;598(22):2788-2806. doi: 10.1002/1873-3468.14839. Epub 2024 Mar 1.
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Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents.
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3
Polycomb group proteins in cancer: multifaceted functions and strategies for modulation.
NAR Cancer. 2021 Oct 4;3(4):zcab039. doi: 10.1093/narcan/zcab039. eCollection 2021 Dec.
5
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12.
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Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.
Am J Hum Genet. 2015 Dec 3;97(6):869-77. doi: 10.1016/j.ajhg.2015.10.013. Epub 2015 Nov 19.
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Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins.
J Zhejiang Univ Sci B. 2014 May;15(5):412-28. doi: 10.1631/jzus.B1400077.

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2
Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells.
Cell Stem Cell. 2012 Jan 6;10(1):47-62. doi: 10.1016/j.stem.2011.12.006.
3
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.
Cancer Cell. 2011 Nov 15;20(5):563-75. doi: 10.1016/j.ccr.2011.09.008.
4
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15751-6. doi: 10.1073/pnas.1111498108. Epub 2011 Sep 6.
7
Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7042-7. doi: 10.1073/pnas.0912041107. Epub 2010 Mar 26.
9
Misguided transcriptional elongation causes mixed lineage leukemia.
PLoS Biol. 2009 Nov;7(11):e1000249. doi: 10.1371/journal.pbio.1000249. Epub 2009 Nov 24.

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