Pharmaceutics and Drug Delivery, Louvain Drug Research Institute, Université catholique de Louvain, 1200 Brussels, Belgium.
J Control Release. 2013 Oct 28;171(2):208-15. doi: 10.1016/j.jconrel.2013.07.015. Epub 2013 Jul 25.
Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes. Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days. In conclusion, we demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds.
伤口愈合是一个复杂的过程，涉及许多相互依存和重叠的生理作用序列。聚（乳酸-共-乙醇酸）（PLGA）聚合物释放的外源性乳酸加速了血管生成和伤口愈合过程。姜黄素是一种众所周知的局部伤口愈合剂，可用于正常和糖尿病受损的伤口。因此，我们假设包封姜黄素的 PLGA 纳米粒子可以大大加速伤口愈合。在全厚度切除性伤口愈合小鼠模型中，PLGA-姜黄素纳米粒子的伤口愈合活性比 PLGA 或姜黄素高两倍。组织学和 RT-PCR 研究证实，PLGA-姜黄素纳米粒子表现出更高的再上皮化、肉芽组织形成和抗炎潜力。PLGA 纳米粒子为包封的姜黄素提供了多种益处，如防止光降解、提高水溶性，并在 8 天的时间内持续释放姜黄素。总之，我们证明了 PLGA 中的乳酸和包封的姜黄素的协同作用对伤口的主动愈合具有积极作用。
