Utpal Biswajit Kumar, Sutradhar Baishakhi, Zehravi Mehrukh, Sweilam Sherouk Hussein, Panigrahy Uttam Prasad, Urs Deepadarshan, Fatima Ayesha Farhath, Nallasivan P Kumar, Chhabra Gurmeet Singh, Sayeed Mohammed, Alshehri Mohammed Ali, Rab Safia Obaidur, Khan Sharuk L, Emran Talha Bin
Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, 1207, Bangladesh.
Department of Microbiology, Gono University (Bishwabidyalay), Nolam, Mirzanagar, Savar, Dhaka, 1344, Bangladesh.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):2459-2485. doi: 10.1007/s00210-024-03538-1. Epub 2024 Oct 25.
Wound healing is a multifaceted, complex process that factors like aging, metabolic diseases, and infections may influence. The potentiality of polyphenols, natural compounds, has shown anti-inflammatory and antimicrobial properties in promoting wound healing and their potential applications in wound management. The studies reviewed indicate that polyphenols have multiple mechanisms that promote wound healing. This involves enhancing antioxidant defenses, reducing oxidative stress, modulating inflammatory responses, improving healing times, reducing infection rates, and enhancing tissue regeneration in clinical trials and in vivo and in vitro studies. Polyphenols have been proven to be effective in managing hard-to-heal wounds, especially in diabetic and elderly populations. Polyphenols have shown significant benefits in promoting angiogenesis and stimulating collagen synthesis. Polyphenol treatment has been demonstrated to have therapeutic effects in wound healing and chronic wound management. Their ability to regulate key healing processes makes them suitable for new wound care products and treatments. Future research should enhance formulations and delivery methods to optimize polyphenols' bioavailability and therapeutic efficacy in wound management approaches.
伤口愈合是一个多方面的复杂过程，衰老、代谢疾病和感染等因素都可能对其产生影响。多酚这种天然化合物具有抗炎和抗菌特性，在促进伤口愈合方面展现出潜力，及其在伤口管理中的潜在应用。所综述的研究表明，多酚具有多种促进伤口愈合的机制。这包括在临床试验以及体内和体外研究中增强抗氧化防御、减轻氧化应激、调节炎症反应、缩短愈合时间、降低感染率以及促进组织再生。已证明多酚在处理难愈合伤口方面有效，尤其是在糖尿病患者和老年人群体中。多酚在促进血管生成和刺激胶原蛋白合成方面显示出显著益处。多酚治疗已被证明在伤口愈合和慢性伤口管理中具有治疗效果。它们调节关键愈合过程的能力使其适用于新型伤口护理产品和治疗方法。未来的研究应改进配方和给药方式，以优化多酚在伤口管理方法中的生物利用度和治疗效果。
