Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.
J Ethnopharmacol. 2013 Sep 16;149(2):570-5. doi: 10.1016/j.jep.2013.07.023. Epub 2013 Jul 23.
The stem bark of Garcinia livingstonei is used traditionally as a skin lightening agent.
To isolate and identify compounds responsible for the observed skin lightening activity of Garcinia livingstonei and to evaluate their cytotoxicity.
Constituents of the stem bark and fruits of Garcinia livingstonei were isolated using chromatographic techniques and structures were determined using 1D and 2D NMR and MS analysis. MeWo cells were used to evaluate the cytotoxicity and impact on melanin levels of extracts and compounds isolated, in vitro.
Twelve known compounds, morelloflavone (1), morelloflavone-7″-sulphate (2), guttiferone A (3), sargaol (4), isojacareubin (5), 6-deoxyisojacareubin (6) and in addition to the common triterpenoids, betulin, betulin aldehyde, lupeol, lupenone, euphol and stigmasterol were isolated in this investigation. Morelloflavone, morelloflavone-7″-sulphate and sargaol, were found to be considerably less cytotoxic and more effective as skin lightening agents than hydroquinone.
A range of compounds was isolated from the stem bark and fruit of Garcinia livingstonei. Although the bark extract contained the cytotoxic guttiferone A, it was found to be less toxic than hydroquinone, and morelloflavone, the 7″-sulphate derivative and sargaol show potential for development as depigmentation/skin lightening agents.
藤黄属荔枝的茎皮被传统用作皮肤增白剂。
分离并鉴定负责藤黄属荔枝观察到的皮肤增白活性的化合物，并评估其细胞毒性。
使用色谱技术从藤黄属荔枝的茎皮和果实中分离出成分，并使用 1D 和 2D NMR 和 MS 分析确定结构。在体外，使用 MeWo 细胞评估提取物和分离化合物的细胞毒性以及对黑色素水平的影响。
在本次研究中分离出了 12 种已知化合物，即杨梅素（1）、杨梅素-7″-硫酸盐（2）、吉马酮 A（3）、sargaol（4）、异山姜黄素（5）、6-去氧异山姜黄素（6）以及常见的三萜类化合物，如桦木醇、桦木醛、羽扇豆醇、羽扇豆酮、 euphol 和豆甾醇。与对苯二酚相比，杨梅素、杨梅素-7″-硫酸盐和 sargaol 的细胞毒性明显较低，且作为皮肤增白剂的效果更好。
从藤黄属荔枝的茎皮和果实中分离出了一系列化合物。尽管树皮提取物含有细胞毒性的吉马酮 A，但它被发现比对苯二酚毒性更小，而杨梅素、7″-硫酸盐衍生物和 sargaol 显示出作为脱色/皮肤增白剂的开发潜力。
