Chung K W
Department of Anatomical Sciences, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73190.
Toxicology. 1990 Jun;62(3):285-95. doi: 10.1016/0300-483x(90)90052-i.
The present study was carried out to investigate if ethanol alters aromatization of androgens and concentrations of hepatic estrogen and androgen receptors. Hepatic aromatization of androgen to estrogen was significantly increased by ethanol administration. There was a significant increase in serum estrogen level but a decreased circulating testosterone level in alcohol-fed rats. Furthermore, the concentration of estrogen receptors in liver cytosol was significantly higher in alcohol-fed rats (37 +/- 5.3 fmol/mg protein), as compared to the intact control value (21 +/- 4.8 fmol/mg protein). However, hepatic androgen receptor levels were much lower (4.4 +/- 0.5) in alcohol-fed rats than those (10.2 +/- 1.4 fmol/mg protein) in control animals. Similarly, castration increased hepatic aromatization of androgens and concentrations of serum estrogen and hepatic estrogen receptors, but it decreased contents of circulating androgen and hepatic androgen receptors. These findings indicate that alcohol administration is considered a chemical form of castration, altering the hepatic steroid metabolism and sex hormone receptor contents and contributing to the pathogenesis of feminization. A combination of alcohol-feeding and castration has no synergistic effect on the hepatic steroid receptors and aromatization, but this combination does have a more profound effect in lowering the concentration of circulating androgen.
本研究旨在探讨乙醇是否会改变雄激素的芳香化作用以及肝脏雌激素和雄激素受体的浓度。给予乙醇后，肝脏中雄激素向雌激素的芳香化作用显著增强。在喂食酒精的大鼠中，血清雌激素水平显著升高，但循环睾酮水平降低。此外，与完整对照组值（21±4.8 fmol/mg蛋白质）相比，喂食酒精的大鼠肝脏细胞质中雌激素受体的浓度显著更高（37±5.3 fmol/mg蛋白质）。然而，喂食酒精的大鼠肝脏雄激素受体水平（4.4±0.5）远低于对照动物（10.2±1.4 fmol/mg蛋白质）。同样，去势会增加肝脏中雄激素的芳香化作用以及血清雌激素和肝脏雌激素受体的浓度，但会降低循环雄激素和肝脏雄激素受体的含量。这些发现表明，给予酒精被认为是一种化学去势形式，会改变肝脏类固醇代谢和性激素受体含量，并导致女性化的发病机制。酒精喂养和去势的联合对肝脏类固醇受体和芳香化作用没有协同作用，但这种联合在降低循环雄激素浓度方面具有更深远的影响。
