Nano-organic Photoelectronic Laboratory and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
Nanoscale. 2013 Sep 7;5(17):8172-6. doi: 10.1039/c3nr01879b.
One-dimensional nanowire (NW) optical sensors have attracted great attention as promising nanoscale tools for applications such as probing inside living cells. However, achieving single molecule detection on NW sensors remains an interesting and unsolved problem. In the present paper, we investigate single-molecule detection (SMD) on a single SiNW based surface-enhanced Raman scattering (SERS) sensor, fabricated by controllably depositing silver nanoparticles on a SiNW (AgNP-SiNW). Both Raman spectral blinking and bi-analyte approaches are performed in aqueous solution to investigate SMD on individual SiNW SERS sensors. The results extend the functions of the SiNW sensor to SMD and provide insight into the molecule level illustration on the sensing mechanism of the nanowire sensor.
一维纳米线（NW）光学传感器作为探测活细胞内部等应用的有前途的纳米级工具引起了极大的关注。然而，在 NW 传感器上实现单分子检测仍然是一个有趣且尚未解决的问题。在本文中，我们研究了基于单个 SiNW 的表面增强拉曼散射（SERS）传感器上的单分子检测（SMD），该传感器通过在 SiNW（AgNP-SiNW）上可控地沉积银纳米颗粒来制备。在水溶液中进行拉曼光谱闪烁和双分析物方法，以研究单个 SiNW SERS 传感器上的 SMD。结果将 SiNW 传感器的功能扩展到 SMD，并深入了解纳米线传感器的传感机制的分子水平说明。
