Büyükkaya Eyüp, Evliyaoğlu Osman, Islamoğlu Yahya, Cil Habib, Karakaş Mehmet Fatih, Akçay Adnan Burak, Bilen Perihan, Kurt Mustafa, Şen Nihat, Ertas Faruk, Mete Nuriye
1Department of Cardiology , School of Medicine of Mustafa Kemal University, Hatay, 2Department of Medical Biochemistry, School of Medicine of Dicle University, Diyarbakır, 3Department of Cardiology, School of Medicine of Dicle University, Diyarbakır; Turkey.
Med Glas (Zenica). 2013 Aug;10(2):229-33.
To evaluate the relationship between the levels of plasma coenzyme Q10 (CoQ10), a known antioxidant, and severity of the coronary atherosclerosis (AS) measured by Gensini score.
Patients with coronary artery disease (CAD) were enrolled to the study between 2010 and 2011 in cardiology outpatient clinics. They were admitted for diagnostic coronary angiography or angioplasty for typical indications. The Gensini scoring system was used to calculate CAD severity. Serum CoQ10, total cholesterol (TC), HDL cholesterol, LDL cholesterol, and triglyceride levels were assessed.
One hundred thirteen subjects (83 CAD, 30 controls) were included. The patients with CAD were separated into three groups according to Gensini score. The serum levels of CoQ10, CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates in the subjects of mild and severe AS groups were significantly lower than the control group ( p less than 0.016 for all control vs. AS group comparisons). There were no significant differences in serum levels of CoQ10 and CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates between the mild and severe AS groups.
This study revealed that although the serum CoQ10 levels were lower in stable CAD, there was no relationship between the severity of CAD and serum CoQ10 levels in patients with stable angina pectoris.
评估已知抗氧化剂血浆辅酶Q10（CoQ10）水平与通过Gensini评分测量的冠状动脉粥样硬化（AS）严重程度之间的关系。
2010年至2011年期间，在心脏病门诊招募冠心病（CAD）患者。他们因典型适应症接受诊断性冠状动脉造影或血管成形术。使用Gensini评分系统计算CAD严重程度。评估血清CoQ10、总胆固醇（TC）、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯水平。
纳入113名受试者（83名CAD患者，30名对照）。根据Gensini评分将CAD患者分为三组。轻度和重度AS组受试者的血清CoQ10、CoQ10/TC、CoQ10/LDL-C、CoQ10/TG比率均显著低于对照组（所有对照组与AS组比较，p均小于0.016）。轻度和重度AS组之间的血清CoQ10水平以及CoQ10/TC、CoQ10/LDL-C、CoQ10/TG比率无显著差异。
本研究表明，尽管稳定型CAD患者的血清CoQ10水平较低，但稳定型心绞痛患者的CAD严重程度与血清CoQ10水平之间无相关性。
