Gong Ping, Li Sha, Hu Liangyan, Luo SongHui, Li JianJun, Jiang Hong
Department of Cardiology, Wuhan University People's Hospital, Wuhan 430060, China.
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Zhonghua Xin Xue Guan Bing Za Zhi. 2015 May;43(5):404-7.
To find a potential link among ABO blood group, lipid profiles and coronary artery disease (CAD) and to estimate the effect size of connection using mediation analysis model.
A total of 898 consecutive patients undergoing coronary angiography were enrolled, and divided into CAD group and non-CAD group according to angiographic findings. According to ABO blood group, patients were divided into O blood group and non-O blood group, as well as A blood group and non-A blood group. Baseline characteristics among various groups were compared and the association of ABO blood group, CAD and lipid profile was explored.
Subjects of blood type A had higher concentration of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) compared with that of non-A type (TC: (4.43 ± 1.12) mmol/L vs. (4.18 ± 1.09) mmol/L, LDL-C: (2.79 ± 0.99) mmo/L vs. (2.59 ± 1.01) mmol/L, all P < 0.01). TC and LDL-C were significantly higher while high density lipoprotein cholesterol (HDL-C) and ApoA I levels were significantly lower in CAD group than in non-CAD group (TC: (4.36 ± 1.05) mmol/L vs. (4.13 ± 1.16) mmol/L, LDL-C: (2.61 ± 0.87) mmol/L vs. (2.47 ± 0.94) mmol/L; ApoA I: (1.38 ± 0.29) mmol/L vs. (1.45 ± 0.33) mmol/L; all P < 0.01). After adjustment for traditional cardiovascular risk factors, blood group A and TC remained significantly associated with the risk of CAD (OR = 1.88, 95% CI 1.280-2.774, P < 0.01; OR = 1.03, 95% CI 1.018-1.033, P < 0.01, respectively). Specially, mediation analysis indicated that 10.5% of the effect of A blood group on CAD was mediated by TC levels (P < 0.01).
Our data indicate that there is an association between ABO blood group, TC levels and risk of CAD. Around 10.5% of the effect of A blood group on CAD is mediated by TC levels.
探寻ABO血型、血脂谱与冠状动脉疾病（CAD）之间的潜在联系，并使用中介分析模型评估关联的效应大小。
共纳入898例连续接受冠状动脉造影的患者，根据造影结果分为CAD组和非CAD组。根据ABO血型，患者分为O血型组和非O血型组，以及A血型组和非A血型组。比较各组的基线特征，探讨ABO血型、CAD与血脂谱之间的关联。
与非A型相比，A型血受试者的总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）浓度更高（TC：(4.43±1.12)mmol/L对(4.18±1.09)mmol/L，LDL-C：(2.79±0.99)mmol/L对(2.59±1.01)mmol/L，均P<0.01）。CAD组的TC和LDL-C显著更高，而高密度脂蛋白胆固醇（HDL-C）和载脂蛋白A I水平显著低于非CAD组（TC：(4.36±1.05)mmol/L对(4.13±1.16)mmol/L，LDL-C：(2.61±0.87)mmol/L对(2.47±0.94)mmol/L；载脂蛋白A I：(1.38±0.29)mmol/L对(1.45±0.33)mmol/L；均P<0.01）。在调整传统心血管危险因素后，A型血和TC仍与CAD风险显著相关（OR=1.88，95%CI 1.280 - 2.774，P<0.01；OR=1.03，95%CI 1.018 - 1.033，P<0.01）。特别地，中介分析表明A型血对CAD的影响中有10.5%由TC水平介导（P<0.01）。
我们的数据表明ABO血型、TC水平与CAD风险之间存在关联。A型血对CAD的影响约10.5%由TC水平介导。
