Al Namat Razan, Al Namat Dina, Ciocoiu Manuela, Hînganu Marius Valeriu, Șorodoc Laurențiu, Șorodoc Victorița, Foia Liliana Georgeta, Florea Laura, Vlad Cristiana, Tănasă Ana, Constantin Mihai, Cioloca Daniel, Bădescu Minerva Codruța, Bazyani Amin, Felea Maura
Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy Iași, 700115 Iasi, Romania.
"Prof. George I.M. Georgescu" Institute of Cardiovascular Diseases Iași, 700503 Iasi, Romania.
J Cardiovasc Dev Dis. 2022 Jul 28;9(8):242. doi: 10.3390/jcdd9080242.
(1) Background: The heart-type fatty acid-binding protein (H-FABP) is a specific myocardial biomarker and high levels indicate ischemia regardless of patient-reported symptoms. Concurrently, major adverse cardiovascular events and surgery such as coronary artery by-pass grafting (CABG) cause substantial psycho-emotional distress e.g., depression and anxiety. Comprehensive cardiac rehabilitation is, therefore, essential to both physical and psychological recovery. (2) Methods: This is a unicentric, prospective study on 120 consecutive post-CABG patients undergoing a 6-month cardiac rehabilitation program based on physical exercise, Mediterranean diet principles, and Q10 coenzyme antioxidant supplements. H-FABP levels, depression, and anxiety scores (Hamilton HAM-D and HAM-A scales) were monitored after surgery and at 6 months. (3) Results: Mean H-FABP dropped from 60.56 to 4.81. Physical ability increased from 1-2 to 4-5 METS. Mean depression and anxiety improved from 15.88 to 6.96 and from 25.13 to 15.68, respectively. Median scores went down 50% for depression and 9% for anxiety. Explored associations between H-FABP and psycho-emotional status were statistically insignificant. (4) Conclusions: patients adhered to the program and improved significantly in all studied aspects. Clinical significance is discussed in the context of countries like Romania, where such programs are limited by systemic and financial constraints. Further research directions are identified.
(1) 背景：心脏型脂肪酸结合蛋白（H-FABP）是一种特异性心肌生物标志物，无论患者报告的症状如何，其高水平都表明存在缺血。同时，主要不良心血管事件和手术，如冠状动脉搭桥术（CABG），会导致严重的心理情绪困扰，如抑郁和焦虑。因此，全面的心脏康复对于身体和心理恢复都至关重要。(2) 方法：这是一项单中心前瞻性研究，对120例连续接受CABG手术的患者进行了为期6个月的心脏康复计划，该计划基于体育锻炼、地中海饮食原则和辅酶Q10抗氧化补充剂。在手术后和6个月时监测H-FABP水平、抑郁和焦虑评分（汉密尔顿HAM-D和HAM-A量表）。(3) 结果：H-FABP的平均值从60.56降至4.81。身体能力从1 - 2代谢当量增加到4 - 5代谢当量。平均抑郁和焦虑分别从15.88改善至6.96以及从25.13改善至15.68。抑郁的中位数得分下降了50%，焦虑的中位数得分下降了9%。探索的H-FABP与心理情绪状态之间的关联在统计学上无显著意义。(4) 结论：患者坚持该计划，在所有研究方面均有显著改善。在罗马尼亚等国家的背景下讨论了临床意义，在这些国家，此类计划受到系统和财政限制。确定了进一步的研究方向。
