Will D H, Hicks J L, Card C S, Alexander A F
J Appl Physiol. 1975 Mar;38(3):491-4. doi: 10.1152/jappl.1975.38.3.491.
This study examines the hypothesis that susceptibility of cattle to high-altitude pulmonary hypertension and heart failure (high mountain disease) is genetically transmitted. Eight offspring of cattle recovered from high mountain disease were considered "susceptible." Eleven offspring of healthy cattle residing at high altitude were considered "resistant." At the resident altitude of 1,524 m, 10-day-old susceptible calves had higher pulmonary arterial pressures than did resistant calves (34 vs.21 mmHg), but at 90 days of age the pressures for the two groups were similar (26 vs. 24 mmHg). After 64 days of exposure to an altitude of 3,048 m, the susceptible calves (87 +/- 7 (SE) vs. 40 +/- 3 mmHg). By 124 days at 3,048 m, all susceptible but none of the resistant calves had developed heart failure. The results indicated that susceptibility to pulmonary hypertension at high altitude was inherited. Susceptible cattle may provide a useful model of human hypoxic pulmonary hypertension.
本研究检验了一个假设，即牛对高原肺动脉高压和心力衰竭（高山病）的易感性是由基因传递的。从高山病中康复的8头牛的后代被视为“易感”。居住在高海拔地区的健康牛的11个后代被视为“抗性”。在海拔1524米的居住地，10日龄的易感犊牛肺动脉压高于抗性犊牛（34对21毫米汞柱），但在90日龄时，两组的压力相似（26对24毫米汞柱）。在暴露于海拔3048米64天后，易感犊牛（87±7（标准误）对40±3毫米汞柱）。到在3048米处124天时，所有易感犊牛但没有抗性犊牛出现心力衰竭。结果表明，高原肺动脉高压的易感性是可遗传的。易感牛可能为人类低氧性肺动脉高压提供一个有用的模型。
