Kobayashi Hirotoshi, Miyata Hiroaki, Gotoh Mitsukazu, Baba Hideo, Kimura Wataru, Kitagawa Yuko, Nakagoe Tohru, Shimada Mitsuo, Tomita Naohiro, Sugihara Kenichi, Mori Masaki
The Japanese Society of Gastroenterological Surgery, Database Committee Working Group, Tokyo, Japan,
J Gastroenterol. 2014 Jun;49(6):1047-55. doi: 10.1007/s00535-013-0860-8. Epub 2013 Jul 27.
Right hemicolectomy is a very common procedure throughout the world, although this procedure is known to carry substantial surgical risks. The present study aimed to develop a risk model for right hemicolectomy outcomes based on a nationwide internet-based database.
The National Clinical Database (NCD) collected records on over 1,200,000 surgical cases from 3,500 Japanese hospitals in 2011. After data cleanup, we analyzed 19,070 records regarding right hemicolectomy performed between January 2011 and December 2011.
The 30-day and operative mortality rates were 1.1 and 2.3 %, respectively. The 30-day mortality rates of patients after elective and emergency surgery were 0.7 and 6.0 %, respectively (P < 0.001). The odds ratios of preoperative risk factors for 30-day mortality were: platelet <50,000/μl, 5.6; ASA grade 4 or 5, 4.0; acute renal failure, 3.2; total bilirubin over 3 mg/dl, 3.1; and AST over 35 U/l, 3.1. The odds ratios for operative mortality were: previous peripheral vascular disease, 3.1; cancer with multiple metastases, 3.1; and ASA grade 4 or 5, 2.9. Sixteen and 26 factors were selected for risk models of 30-day and operative mortality, respectively. The c-index of both models was 0.903 [95 % confidence interval (CI) 0.877-0.928; P < 0.001] and 0.891 (95 % CI 0.873-0.908; P < 0.001), respectively.
We performed the first reported risk stratification study for right hemicolectomy based on a nationwide internet-based database. The outcomes of right hemicolectomy in the nationwide population were satisfactory. The risk models developed in this study will help to improve the quality of surgical practice.
右半结肠切除术在全球是一种非常常见的手术,尽管已知该手术存在重大手术风险。本研究旨在基于全国性的互联网数据库开发一种右半结肠切除术预后的风险模型。
国家临床数据库(NCD)收集了2011年来自3500家日本医院的超过120万例手术病例的记录。在数据清理后,我们分析了2011年1月至2011年12月期间进行的19070例右半结肠切除术的记录。
30天和手术死亡率分别为1.1%和2.3%。择期和急诊手术后患者的30天死亡率分别为0.7%和6.0%(P<0.001)。30天死亡率术前危险因素的比值比为:血小板<50,000/μl,5.6;美国麻醉医师协会(ASA)分级4或5级,4.0;急性肾衰竭,3.2;总胆红素超过3mg/dl,3.1;谷草转氨酶(AST)超过35U/l,3.1。手术死亡率的比值比为:既往周围血管疾病,3.1;多发转移癌,3.1;ASA分级4或5级,2.9。分别为30天和手术死亡率的风险模型选择了16个和26个因素。两个模型的c指数分别为0.903[95%置信区间(CI)0.877 - 0.928;P<0.001]和0.891(95%CI 0.873 - 0.908;P<0.001)。
我们基于全国性的互联网数据库进行了首次报道的右半结肠切除术风险分层研究。全国人群中右半结肠切除术的结果令人满意。本研究开发的风险模型将有助于提高手术实践质量。