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右侧结肠癌性梗阻急诊内镜下自膨式金属支架置入术无透视辅助的疗效及安全性分析。

Efficacy and Safety Analysis of Emergency Endoscopic Self-Expanding Metal Stent Placement Without Fluoroscopic Assistance for Right-Sided Colonic Cancer Obstruction.

机构信息

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Department of Emergency@Trauma Center, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

出版信息

Ann Surg Oncol. 2024 May;31(5):3212-3221. doi: 10.1245/s10434-024-14909-6. Epub 2024 Feb 13.

DOI:10.1245/s10434-024-14909-6
PMID:38349564
Abstract

BACKGROUND

Traditionally, surgical treatment is recommended for right-sided colonic cancer obstruction (RCCO); however, the literature comparing surgical or non-surgical procedures is lacking.

METHODS

Patients included in this study were divided into two groups: one group received elective surgery after self-expanding metal stent (SEMS) placement, i.e., the bridge to surgery (BTS) group, and one group received emergency surgery (ES).

RESULTS

Thirty-five patients were included in the BTS group and 60 patients underwent ES. The technical and clinical success rates for SEMS placement were 100% and 88.6%, respectively, while the short-term complication rates were 51.4% and 33.3% for the BTS and ES groups, respectively (p = 0.082). Overall, 2.9% and 3.3% of postoperative deaths occurred in the BTS and ES groups (p = 1.000). The 1-year overall survival (OS) rates were 91.4% and 88.3% (p = 0.840), 3-year OS rates were 85.7% and 81.7% (p = 0.860), and 5-year OS rates were 82.9% and 76.7% (p = 0.620) in the BTS and ES groups, respectively. No tumor recurrence was found in the BTS group but seven recurrences were found in the ES group (11.7%) [p = 0.091]. Laparoscopic surgery was chosen by 42.9% of patients in the BTS group and 26.7% of patients in the ES group (p = 0.104); however, the length of hospital stay (p = 0.001) was longer in the BTS group.

CONCLUSIONS

In the two groups, no differences were found in terms of postoperative complications and mortality as well as OS. The BTS group preferred to perform laparoscopic surgery and the technical success rate of stenting was high, therefore SEMS for RCCO was considered safe and feasible.

摘要

背景

传统上,建议对右侧结肠癌梗阻(RCCO)进行手术治疗;然而,缺乏比较手术和非手术治疗方法的文献。

方法

本研究将患者分为两组:一组在自膨式金属支架(SEMS)放置后接受择期手术,即桥接手术(BTS)组,另一组接受急诊手术(ES)。

结果

BTS 组纳入 35 例患者,ES 组纳入 60 例患者。SEMS 放置的技术和临床成功率分别为 100%和 88.6%,而 BTS 和 ES 组的短期并发症发生率分别为 51.4%和 33.3%(p=0.082)。总体而言,BTS 和 ES 组的术后死亡率分别为 2.9%和 3.3%(p=1.000)。BTS 和 ES 组的 1 年总生存率(OS)分别为 91.4%和 88.3%(p=0.840),3 年 OS 率分别为 85.7%和 81.7%(p=0.860),5 年 OS 率分别为 82.9%和 76.7%(p=0.620)。BTS 组未发现肿瘤复发,但 ES 组发现 7 例复发(11.7%)[p=0.091]。BTS 组中 42.9%的患者选择腹腔镜手术,而 ES 组中 26.7%的患者选择腹腔镜手术(p=0.104);然而,BTS 组的住院时间更长(p=0.001)。

结论

两组患者术后并发症和死亡率以及 OS 无差异。BTS 组更倾向于进行腹腔镜手术,支架置入的技术成功率较高,因此 SEMS 治疗 RCCO 是安全可行的。

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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020:全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
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Cancer Statistics, 2021.癌症统计数据,2021.
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Self-expandable metallic stenting as a bridge to elective surgery versus emergency surgery for acute malignant right-sided colorectal obstruction.
自膨式金属支架置入术在急性恶性右半结直肠梗阻择期手术与急诊手术中的桥接作用比较。
BMC Surg. 2020 Dec 10;20(1):326. doi: 10.1186/s12893-020-00993-4.
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Endoscopic Self-Expandable Metallic Stent Insertion without Fluoroscopic Guidance Is Feasible and Safe for Acute Colonic Obstruction Caused by Colorectal Cancer.在无荧光镜引导下进行内镜下自膨式金属支架置入术对于结直肠癌所致急性结肠梗阻是可行且安全的。
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Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020.自膨式金属支架治疗结直肠及结直肠外恶性肿瘤:欧洲胃肠道内镜学会(ESGE)指南-2020 年更新
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Comparison of Decompressing Stoma vs Stent as a Bridge to Surgery for Left-Sided Obstructive Colon Cancer.左侧梗阻性结肠癌行减压造口术与支架桥接手术的比较。
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