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担子菌病是一种神秘的真菌感染,可模仿小肠和结肠肿瘤,并伴有肾功能不全及不良预后。

Basidiobolomycosis a mysterious fungal infection mimic small intestinal and colonic tumour with renal insufficiency and ominous outcome.

作者信息

Zahir Shokouh Taghipour, Sharahjin Naser Sefidrokh, Kargar Saeed

机构信息

Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran.

出版信息

BMJ Case Rep. 2013 Jul 26;2013:bcr2013200244. doi: 10.1136/bcr-2013-200244.

Abstract

Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum a worldwide environmental saprophyte fungus that is potentially a pathogen. B ranarum mainly affects the subcutaneous tissues but gastrointestinal and disseminated infections rarely have been reported previously. We report a case of B ranarum infection in a 12-year-old immunocompetent boy presented with abdominal pain from 2 months earlier before admission in the hospital. Abdominal CT scan revealed a lobulated mass-like lesion in the vicinity of right lower quadrant enveloping ascending colon and terminal ileum with involvement of mesentery. Histopathological examination showed severe full-thickness infiltration of inflammatory cells mainly eosinophils admixed with multinucleated giant cells and large areas of necrosis with granulomatous feature. Periodic acid Schiff staining demonstrated thin-walled septate fungal hyphae's surrounded by eosinophilic material (Splendore-Hoppeli phenomenon) identified as a basidiobolomycosis.

摘要

蛙粪霉病是一种由蛙粪霉引起的罕见真菌感染,蛙粪霉是一种全球范围内的环境腐生真菌,具有潜在致病性。蛙粪霉主要侵犯皮下组织,但此前很少有胃肠道和播散性感染的报道。我们报告一例12岁免疫功能正常男孩的蛙粪霉感染病例,该男孩在入院前2个月出现腹痛。腹部CT扫描显示右下腹附近有一个分叶状肿块样病变,包绕升结肠和回肠末端,累及肠系膜。组织病理学检查显示炎症细胞严重全层浸润,主要为嗜酸性粒细胞,并混有多核巨细胞,大片坏死,具有肉芽肿特征。过碘酸希夫染色显示薄壁分隔真菌菌丝被嗜酸性物质包围(斯普伦多-霍佩利现象),确诊为蛙粪霉病。

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Histological and ultrastructural features of gastrointestinal basidiobolomycosis.胃肠道蛙粪霉病的组织学和超微结构特征
Mycol Res. 2007 Aug;111(Pt 8):926-30. doi: 10.1016/j.mycres.2007.06.009. Epub 2007 Jun 29.

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