Zahir Shokouh Taghipour, Sharahjin Naser Sefidrokh, Kargar Saeed
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran.
BMJ Case Rep. 2013 Jul 26;2013:bcr2013200244. doi: 10.1136/bcr-2013-200244.
Basidiobolomycosis is a rare fungal infection caused by Basidiobolus ranarum a worldwide environmental saprophyte fungus that is potentially a pathogen. B ranarum mainly affects the subcutaneous tissues but gastrointestinal and disseminated infections rarely have been reported previously. We report a case of B ranarum infection in a 12-year-old immunocompetent boy presented with abdominal pain from 2 months earlier before admission in the hospital. Abdominal CT scan revealed a lobulated mass-like lesion in the vicinity of right lower quadrant enveloping ascending colon and terminal ileum with involvement of mesentery. Histopathological examination showed severe full-thickness infiltration of inflammatory cells mainly eosinophils admixed with multinucleated giant cells and large areas of necrosis with granulomatous feature. Periodic acid Schiff staining demonstrated thin-walled septate fungal hyphae's surrounded by eosinophilic material (Splendore-Hoppeli phenomenon) identified as a basidiobolomycosis.
蛙粪霉病是一种由蛙粪霉引起的罕见真菌感染,蛙粪霉是一种全球范围内的环境腐生真菌,具有潜在致病性。蛙粪霉主要侵犯皮下组织,但此前很少有胃肠道和播散性感染的报道。我们报告一例12岁免疫功能正常男孩的蛙粪霉感染病例,该男孩在入院前2个月出现腹痛。腹部CT扫描显示右下腹附近有一个分叶状肿块样病变,包绕升结肠和回肠末端,累及肠系膜。组织病理学检查显示炎症细胞严重全层浸润,主要为嗜酸性粒细胞,并混有多核巨细胞,大片坏死,具有肉芽肿特征。过碘酸希夫染色显示薄壁分隔真菌菌丝被嗜酸性物质包围(斯普伦多-霍佩利现象),确诊为蛙粪霉病。