Department of Pathology, Shiraz University of Medical Sciences, PO Box 71345-1864, Shiraz, Iran.
Transplant Research Center, Shiraz University of Medical Sciences, PO Box 71345-1864, Shiraz, Iran.
J Med Microbiol. 2012 Dec;61(Pt 12):1770-1774. doi: 10.1099/jmm.0.046839-0. Epub 2012 Aug 23.
Zygomycosis is characterized by tissue invasion with broad, non-septate hyphae of species such as Rhizopus, Rhizomucor, Lichtheimia (Absidia) and Basidiobolus. Basidiobolus ranarum usually causes subcutaneous infection, and gastrointestinal manifestations in immunocompetent patients have rarely been reported. It is difficult to diagnose gastrointestinal basidiobolomycosis because of the non-specific clinical presentation and the absence of a definite risk factor. This study identified 14 cases of gastrointestinal basidiobolomycosis, all of which were diagnosed after surgery by characteristic histopathological findings. Diagnosis of this disease requires a high index of suspicion in patients presenting with abdominal symptoms, fever, gastrointestinal mass and eosinophilia accompanied by a high erythrocyte sedimentation rate.
接合菌病的特征是组织浸润伴有宽、无隔的菌丝，例如根霉属、毛霉属、粘帚霉属（伞菌属）和双极虫属。蛙粪霉通常引起皮下感染，免疫功能正常患者的胃肠道表现很少有报道。由于非特异性临床表现和缺乏明确的危险因素，胃肠道芽生菌病的诊断较为困难。本研究鉴定了 14 例胃肠道芽生菌病，所有病例均通过特征性组织病理学发现在手术后诊断。患有腹部症状、发热、胃肠道肿块和伴有高红细胞沉降率的嗜酸性粒细胞增多症的患者，如果怀疑该疾病，需要高度怀疑。
