Department of Emergency Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui City, People's Republic of China.
Eur J Cancer Prev. 2012 Sep;21(5):432-41. doi: 10.1097/CEJ.0b013e32834f7514.
The relationships between the NAD(P)H quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of digestive tract (DT) cancer are controversial. Therefore, we performed a meta-analysis to assess the relationships. The databases of Medline, Embase, and WanFang (updated to 15 May 2011) were reviewed. Odds ratios and 95% confidence intervals were calculated to assess the strength of the associations. Overall, 21 individual case-control studies in 20 papers with 5340 cases and 5911 controls were included in this meta-analysis. The results of combined analyses indicated that the T allele of NQO1 C609T was significantly associated with increased risk of DT cancer [odds ratio (95% CI): 1.58 (1.22-2.07) for TT vs. CC and 1.13 (1.06-1.22) for T carriers vs. C carriers]. Subgroup analyses for different types of cancers indicated that the T allele was significantly associated with an increased risk of gastric cancer [1.19 (1.13-1.47) for T carriers vs. C carriers], but not with esophageal cancer [1.05 (0.86-1.27) for T carriers vs. C carriers] and colorectal cancer [1.09 (0.98-1.21) for T carriers vs. CC]. Subgroup analyses for ethnicities and countries indicated that the T allele was associated with risk of DT cancer among Europeans [1.52 (1.05-2.19) for TT vs. CC] and Asians [1.52 (1.05-2.19) for TT vs. CC], and German, Indian, and Chinese populations but not among English and Japanese populations. In addition, subgroup analyses also indicated that the T allele was significantly associated with risk of DT cancer in studies with large and small sample sizes and in population-based studies, but not in hospital-based studies. This meta-analysis suggests that NQO1 C609T is significantly associated with risk of DT cancer among both Europeans and Asians, especially gastric cancer. Because of the limited number of cases and controls in the subgroup analyses, more well-designed studies with a large sample of participants are needed to verify our findings.
NAD(P)H 醌氧化还原酶 1（NQO1）C609T 多态性与消化道（DT）癌症风险之间的关系存在争议。因此，我们进行了荟萃分析来评估这些关系。检索了 Medline、Embase 和万方（更新至 2011 年 5 月 15 日）数据库。使用比值比（OR）和 95%置信区间（CI）来评估关联的强度。总体上，纳入了 21 项病例对照研究（20 篇文献），包括 5340 例病例和 5911 例对照。合并分析结果表明，NQO1 C609T 的 T 等位基因与 DT 癌症风险增加显著相关[TT 与 CC 相比的比值比（OR）（95%CI）：1.58（1.22-2.07），TT 与 CC 相比的比值比（OR）（95%CI）：1.13（1.06-1.22）]。不同癌症类型的亚组分析表明，T 等位基因与胃癌风险增加显著相关[1.19（1.13-1.47），TT 与 CC 相比]，但与食管癌[1.05（0.86-1.27），TT 与 CC 相比]和结直肠癌[1.09（0.98-1.21），TT 与 CC 相比]无关。基于种族和国家的亚组分析表明，T 等位基因与欧洲人[TT 与 CC 相比的比值比（OR）（95%CI）：1.52（1.05-2.19）]和亚洲人[TT 与 CC 相比的比值比（OR）（95%CI）：1.52（1.05-2.19）]的 DT 癌症风险相关，与德国、印度和中国人群相关，但与英国和日本人群无关。此外，亚组分析还表明，T 等位基因与大样本量和基于人群的研究中的 DT 癌症风险显著相关，但与基于医院的研究无关。本荟萃分析表明，NQO1 C609T 与欧洲人和亚洲人（尤其是胃癌）的 DT 癌症风险显著相关。由于亚组分析中的病例和对照数量有限，需要进行更多设计良好的、有大量参与者的研究来验证我们的发现。
