中国广西地区性工作者中单纯疱疹病毒 2 型感染的血清阳性率及危险因素分析。
Seropositivity and risk factors for herpes simplex virus type 2 infection among female sex workers in Guangxi, China.
机构信息
National Center for STD Control, and the Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China.
出版信息
PLoS One. 2013 Jul 22;8(7):e69697. doi: 10.1371/journal.pone.0069697. Print 2013.
OBJECTIVES
To determine seropositivity of herpes simplex virus type 2 (HSV-2) infection and associated risk factors among female sex workers (FSWs) in Guangxi, China.
METHODS
A convenience sample of FSWs was recruited from different types of sex work venues in two cities (Wuzhou and Hezhou) in Guangxi. Blood specimens were collected for ELISA-based detection of HSV-2 antibodies to examine the seropositivity of HSV-2 infection. Socio-demographic and behavioral data were collected through a structured questionnaire interview. Association of HSV-2 seropositivity with socio-demographic and behavioral characteristics and HIV status was analyzed.
RESULTS
The overall prevalence of HSV-2 seropositivity among 2453 FSWs was 54.9% (95% confidence interval [CI], 52.9-56.9%). The HSV-2 seropositivity was independently associated with older age, low education level, non-Han minority, migration status, working in lower-tier venues and positive HIV status.
CONCLUSIONS
The study indicates a high prevalence of HSV-2 infection among FSWs, particularly in those working in low-tier venues in study areas, suggesting the needs to further emphasize the inclusion of HSV-2 in surveillance and intervention programs in this population.
目的
在中国广西，确定女性性工作者（FSW）中单纯疱疹病毒 2 型（HSV-2）感染的血清阳性率及其相关危险因素。
方法
从广西两个城市（梧州和贺州）不同类型的性工作场所中抽取方便样本，采集 FSW 的血样，进行基于酶联免疫吸附试验的 HSV-2 抗体检测，以检查 HSV-2 感染的血清阳性率。通过结构化问卷访谈收集社会人口统计学和行为数据。分析 HSV-2 血清阳性率与社会人口统计学和行为特征以及 HIV 状况的关联。
结果
在 2453 名 FSW 中，HSV-2 血清阳性率总体为 54.9%（95%置信区间[CI]，52.9-56.9%）。HSV-2 血清阳性率与年龄较大、教育程度较低、非汉族、流动人口身份、在低级别场所工作以及 HIV 阳性状况独立相关。
结论
本研究表明 FSW 中 HSV-2 感染率较高，尤其是在研究地区低级别场所工作的 FSW 中，这表明需要进一步强调将 HSV-2 纳入该人群的监测和干预计划中。
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