[山东省胶州市女性性工作者中人类免疫缺陷病毒、梅毒、单纯疱疹病毒2型的流行情况及相关危险因素研究]

[Study on the prevalence and associated risk factors related to HIV, syphilis, herpes simplex virus-2 among female sex workers in Jiaozhou, Shandong province].

作者信息

Li Zheng, Li Dongmin, Liu Huixin, Jiang Zhenxia, Zhu Lin, Wang Ning

机构信息

School of Public Health, Peking Union Medical College,Beijing 100730, China.

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Oct;35(10):1099-104.

PMID:25567012

Abstract

OBJECTIVE

To analyze the prevalence rates and associated risk factors on HIV, syphilis, herpes simplex virus-2 (HSV-2) among female sex workers (FSWs) in Jiaozhou, Shandong province.

METHODS

Through convenient sampling, an anonymous questionnaire survey was conducted on female sex workers to collect related information. Blood specimens were drawn for serological tests on HIV, syphilis and HSV-2 antibodies, respectively. Patients with positive results from both treponema pallidum and HSV-2 tested by ELISA method, were defined as being superinfected.

RESULTS

A total of 460 FSWs were recruited in this study. The prevalence rates of HIV, syphilis, HSV-2, and syphilis/HSV-2 superinfection were 0.22% , 5.9% , 43.0% , and 11.7% , respectively. Among the methamphetamine users, the prevalence rates of syphilis, HSV-2, and syphilis/HSV-2 superinfection were 12.4%, 55.2%, and 22.9%, respectively. Results from multivariate analysis showed that factors that significantly associated with syphilis infection would include: methamphetamine use (OR = 3.61, 95% CI:1.62-8.06), having first commercial sex intercourse at under 20 years of age (OR = 2.80, 95% CI:1.15-6.85), more than 2 establishments that the FSWs worked in the last month (OR = 4.37, 95%CI:0.83-22.83). Factors associated with HSV-2 infection were methamphetamine use (OR = 2.30, 95%CI:1.43-3.70), having first commercial sex intercourse at under 20 years of age (OR = 1.77, 95% CI:1.16-2.69), working at low-end establishments (OR = 2.61, 95%CI:1.66-4.10), working at the local sex-work venues for more than one year (OR = 2.01, 95% CI:1.28-3.14), with low education backgrounds (OR = 2.27, 95% CI:1.18-4.36), using methamphetamine (OR = 3.95, 95% CI:2.09-7.44), low education background (OR = 2.43, 95% CI: 1.10-5.36), 21-30 year-olds (OR = 2.95, 95%CI:1.08-8.03), older than 31 years of age (OR = 7.05, 95% CI:2.48-20.01) etc., were independent risk factors associated with the superinfection of syphilis and HSV-2.

CONCLUSION

The prevalence rates of syphilis, HSV-2 and syphilis/HSV-2 superinfection were relatively high among FSWs in Jiaozhou, especially among the FSWs who were methamphetamine users.

摘要

目的

分析山东省胶州市女性性工作者中艾滋病病毒（HIV）、梅毒、单纯疱疹病毒2型（HSV-2）的感染率及相关危险因素。

方法

采用方便抽样的方法，对女性性工作者进行匿名问卷调查以收集相关信息。分别采集血液标本进行HIV、梅毒和HSV-2抗体的血清学检测。梅毒螺旋体和HSV-2酶联免疫吸附试验结果均为阳性的患者被定义为重叠感染。

结果

本研究共招募了460名女性性工作者。HIV、梅毒、HSV-2以及梅毒/HSV-2重叠感染的感染率分别为0.22%、5.9%、43.0%和11.7%。在使用甲基苯丙胺的人群中，梅毒、HSV-2以及梅毒/HSV-2重叠感染的感染率分别为12.4%、55.2%和22.9%。多因素分析结果显示，与梅毒感染显著相关的因素包括：使用甲基苯丙胺（比值比[OR]=3.61，95%置信区间[CI]：1.62-8.06）、首次商业性行为发生在20岁以下（OR=2.80，95%CI：1.15-6.85）、女性性工作者上个月工作的场所超过2个（OR=4.37，95%CI：0.83-22.83）。与HSV-2感染相关的因素有使用甲基苯丙胺（OR=2.30，95%CI：1.43-3.70）、首次商业性行为发生在20岁以下（OR=1.77，95%CI：1.16-2.69）、在低端场所工作（OR=2.61，95%CI：1.66-4.10）、在当地性工作场所工作超过1年（OR=2.01，95%CI：1.28-3.14）、教育程度低（OR=2.27，95%CI：1.18-4.36）、使用甲基苯丙胺（OR=3.95，95%CI：2.09-7.44）、教育程度低（OR=2.43，95%CI：1.10-5.36）、21-30岁（OR=2.95，95%CI：1.08-8.03）、31岁以上（OR=7.05，95%CI：2.48-20.01）等，是梅毒和HSV-2重叠感染的独立危险因素。