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氟喹诺酮类药物在癌症治疗中可能作用的洞察观点。

Insight view on possible role of fluoroquinolones in cancer therapy.

机构信息

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.

出版信息

Curr Top Med Chem. 2013 Aug;13(16):2076-96. doi: 10.2174/15680266113139990133.

Abstract

Cancer is a disease without limits turning out to be prime cause for raising death toll around the world. Several treatment strategies including chemotherapy, surgery and radiotherapy are being employed worldwide to combat this disease. Due to the unwanted effects of currently available therapies, scientific community is immensely interested in exploring newer alternative pathways. Fluoroquinolones have been employed as potent anti-microbial agents for last few decades and now being looked up as potential therapeutic agents in the other ailments also. Several research endeavours are carried out in different parts of the world to focus on the prospective role of fluoroquinolones in carcinogenesis and mutagenesis. This article is an earnest attempt to present recent research work carried out on fluoroquinolones in the context to cancer treatment therapies.

摘要

癌症是一种无界限的疾病,是导致全球死亡人数上升的主要原因。目前,全球范围内采用了多种治疗策略,包括化疗、手术和放疗,以对抗这种疾病。由于现有疗法的副作用,科学界对探索新的替代途径非常感兴趣。氟喹诺酮类药物作为有效的抗菌药物已经使用了几十年,现在也被视为其他疾病的潜在治疗药物。世界各地的许多研究工作都在致力于研究氟喹诺酮类药物在致癌和致突变方面的潜在作用。本文旨在就癌症治疗疗法方面,介绍氟喹诺酮类药物的最新研究工作。

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