Organic Research Laboratory, Department of Bioresources and Food Science, College of Life and Environmental Sciences, Konkuk University, Seoul- 143 701, South Korea.
Mini Rev Med Chem. 2013 Oct;13(11):1579-601. doi: 10.2174/13895575113139990073.
This article purposes to provide insights to piperazine based molecular designs that will facilitate drug discovery program in future. In our pursuit to summarize the reservoir of bioactive agents, and in line with the synthetic economy of new heterocycles, many new roles are being identified for the multiple biotargets of piperazine moieties. We mark out how series of different scaffolds provide an extensive range of various piperazine-based analogues displaying antimicrobial, antituberculosis, anticancer, antiviral and antimalarial activities. We believe that piperazine family of compounds, and their various co-components, highlight the existence of several potential leads for the furtherance of novel bioactive agents.
本文旨在为基于哌嗪的分子设计提供深入了解，以促进未来的药物发现计划。在我们总结生物活性物质库的过程中，并且符合新杂环的合成经济性，哌嗪部分的多个生物靶标正在被确定许多新的作用。我们指出，一系列不同的支架如何为各种显示抗菌、抗结核、抗癌、抗病毒和抗疟活性的基于哌嗪的类似物提供广泛的范围。我们相信，哌嗪类化合物及其各种共同成分突出了几个潜在的先导化合物的存在，以推进新型生物活性物质的发展。
