• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

尿酸对早期慢性肾脏病内皮功能障碍的影响及其机制。

Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms.

机构信息

Department of Nephrology, Jinshan Hospital affiliated to Fudan University, No,1508 Longhang Road, Jinshan District, Shanghai 201508, China.

出版信息

Eur J Med Res. 2013 Jul 30;18(1):26. doi: 10.1186/2047-783X-18-26.

DOI:10.1186/2047-783X-18-26
PMID:23895583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3750429/
Abstract

BACKGROUND

An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function. This study aims to explore the relation between UA and endothelial dysfunction in early CKD and its mechanisms in a murine model.

METHODS

The experimental animals were randomly divided into three groups (n = 10): sham-operation group (control group), right nephrectomy only group (CKD group) and right nephrectomy with oxonic potassium group (CKD with hyperuricemia group). Furthermore, we analyzed the relation between UA and endothelial dysfunction indices in early CKD as well as its mechanisms.

RESULTS

Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio. In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase.

CONCLUSIONS

Endothelial dysfunction in the CKD group was significant and had a positive correlation with the level of serum UA. Endothelial dysfunction in early CKD with hyperuricemia is perhaps related to oxidative stress, micro-inflammation and lipid oxidation.

摘要

背景

在慢性肾脏病（CKD）的早期和中期，血清尿酸（UA）升高，加重肾功能恶化。本研究旨在探讨早期 CKD 中 UA 与血管内皮功能障碍的关系及其在小鼠模型中的机制。

方法

实验动物随机分为三组（n = 10）：假手术组（对照组）、单纯右肾切除术组（CKD 组）和右肾切除加氧钾组（高尿酸血症 CKD 组）。进一步分析早期 CKD 中 UA 与血管内皮功能障碍指标的关系及其机制。

结果

线性回归分析显示，血清 UA 水平与血清内皮素-1和胶原 I 阳性面积百分比呈显著正相关，与血清一氧化氮（NO）和 NO/内皮素-1 比值呈显著负相关。此外，血清 UA 水平与血清丙二醛、血清 C 反应蛋白、血清氧化修饰型低密度脂蛋白和血清低密度脂蛋白呈显著正相关，与血清超氧化物歧化酶呈显著负相关。

结论

CKD 组存在明显的血管内皮功能障碍，与血清 UA 水平呈正相关。高尿酸血症早期 CKD 中的血管内皮功能障碍可能与氧化应激、微炎症和脂质氧化有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/5f3cbfce55dc/2047-783X-18-26-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/bfc0498ad7ce/2047-783X-18-26-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/e275c8908c46/2047-783X-18-26-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/5f3cbfce55dc/2047-783X-18-26-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/bfc0498ad7ce/2047-783X-18-26-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/e275c8908c46/2047-783X-18-26-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8fc/3750429/5f3cbfce55dc/2047-783X-18-26-3.jpg

相似文献

1
Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms.尿酸对早期慢性肾脏病内皮功能障碍的影响及其机制。
Eur J Med Res. 2013 Jul 30;18(1):26. doi: 10.1186/2047-783X-18-26.
2
[Oxidative stress and endothelial dysfunction at different serum uric acid levels].[不同血清尿酸水平下的氧化应激与内皮功能障碍]
Zhonghua Nei Ke Za Zhi. 2008 Aug;47(8):638-41.
3
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.ATP敏感性钾通道的激活可保护血管内皮细胞免受高尿酸血症诱导的高血压和肾损伤。
J Hypertens. 2008 Dec;26(12):2326-38. doi: 10.1097/HJH.0b013e328312c8c1.
4
Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K efflux.尿酸通过 ROS 激活和 K+外流调节 NLRP3/IL-1β 信号通路，并进一步诱导早期 CKD 中的血管内皮细胞损伤。
BMC Nephrol. 2019 Aug 14;20(1):319. doi: 10.1186/s12882-019-1506-8.
5
Hyperuricemia induces endothelial dysfunction.高尿酸血症会导致内皮功能障碍。
Kidney Int. 2005 May;67(5):1739-42. doi: 10.1111/j.1523-1755.2005.00273.x.
6
Oral uricase eliminates blood uric acid in the hyperuricemic pig model.口服尿酸酶可降低高尿酸血症猪模型的血尿酸水平。
PLoS One. 2017 Jun 8;12(6):e0179195. doi: 10.1371/journal.pone.0179195. eCollection 2017.
7
Uric acid induced the phenotype transition of vascular endothelial cells induction of oxidative stress and glycocalyx shedding.尿酸诱导血管内皮细胞表型转化 诱导氧化应激和糖萼脱落。
FASEB J. 2019 Dec;33(12):13334-13345. doi: 10.1096/fj.201901148R. Epub 2019 Sep 25.
8
Effects of uric acid on hearts of rats with chronic kidney disease.尿酸对慢性肾脏病大鼠心脏的影响。
Am J Nephrol. 2014;40(4):308-14. doi: 10.1159/000366454. Epub 2014 Oct 17.
9
Hyperuricemia is an independent predictive factor for left ventricular diastolic dysfunction in patients with chronic kidney disease.高尿酸血症是慢性肾脏病患者左心室舒张功能障碍的独立预测因素。
Adv Clin Exp Med. 2015 Jan-Feb;24(1):47-54. doi: 10.17219/acem/38159.
10
High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury.高尿酸和血管紧张素Ⅱ浓度增加协同作用导致内皮损伤。
Mediators Inflamm. 2020 May 22;2020:8387654. doi: 10.1155/2020/8387654. eCollection 2020.

引用本文的文献

1
Pharmacological inhibition of Src family kinases attenuates hyperuricemic nephropathy.Src家族激酶的药理学抑制可减轻高尿酸血症肾病。
Front Pharmacol. 2024 Mar 21;15:1352730. doi: 10.3389/fphar.2024.1352730. eCollection 2024.
2
Caspase-11/GSDMD contributes to the progression of hyperuricemic nephropathy by promoting NETs formation.半胱天冬酶-11/ Gasdermin D通过促进中性粒细胞胞外诱捕网形成，推动高尿酸血症肾病的进展。
Cell Mol Life Sci. 2024 Mar 4;81(1):114. doi: 10.1007/s00018-024-05136-z.
3
Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction.

本文引用的文献

1
Uric acid as a target of therapy in CKD.尿酸作为 CKD 治疗靶点。
Am J Kidney Dis. 2013 Jan;61(1):134-46. doi: 10.1053/j.ajkd.2012.07.021. Epub 2012 Oct 9.
2
Insulin resistance in patients with chronic kidney disease.慢性肾病患者的胰岛素抵抗
J Biomed Biotechnol. 2012;2012:691369. doi: 10.1155/2012/691369. Epub 2012 Aug 7.
3
Cardiovascular disease in chronic kidney disease: untying the Gordian knot.慢性肾脏病中的心血管疾病：解开戈尔迪之结。
长叶勾儿茶生物碱成分通过调节血尿酸水平和缓解炎症反应改善高尿酸血症肾病。
J Nat Med. 2023 Sep;77(4):867-879. doi: 10.1007/s11418-023-01729-3. Epub 2023 Jul 12.
4
Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy.姜黄素调节尿酸肾病大鼠肠道微生物群并改善肾功能。
Ren Fail. 2021 Dec;43(1):1063-1075. doi: 10.1080/0886022X.2021.1944875.
5
The Interventional Effects of Tubson-2 Decoction on Ovariectomized Rats as Determined by a Combination of Network Pharmacology and Metabolomics.基于网络药理学与代谢组学联用探究菟丝子-2号方对去卵巢大鼠的干预作用
Front Pharmacol. 2020 Oct 14;11:581991. doi: 10.3389/fphar.2020.581991. eCollection 2020.
6
Protective Effects and Metabolic Regulatory Mechanisms of Shenyan Fangshuai Recipe on Chronic Kidney Disease in Rats.肾炎方衰方对大鼠慢性肾脏病的保护作用及代谢调节机制
Evid Based Complement Alternat Med. 2020 Aug 25;2020:5603243. doi: 10.1155/2020/5603243. eCollection 2020.
7
Asymptomatic hyperuricemia and coronary flow reserve in patients with metabolic syndrome.代谢综合征患者的无症状高尿酸血症与冠状动脉血流储备
BMC Rheumatol. 2018 Jun 20;2:17. doi: 10.1186/s41927-018-0027-6. eCollection 2018.
8
Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy.3-MA 通过抑制自噬对高尿酸血症肾病具有保护作用。
Clin Sci (Lond). 2018 Nov 2;132(21):2299-2322. doi: 10.1042/CS20180563. Print 2018 Nov 15.
9
Assessment of coronary vascular function with cardiac PET in relation to serum uric acid.利用心脏正电子发射断层扫描评估冠状动脉血管功能与血清尿酸的关系。
PLoS One. 2018 Feb 13;13(2):e0192788. doi: 10.1371/journal.pone.0192788. eCollection 2018.
10
Effects of Allopurinol on Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.别嘌醇对血管内皮功能的影响：一项随机安慰剂对照试验的系统评价和荟萃分析。
Drugs. 2018 Jan;78(1):99-109. doi: 10.1007/s40265-017-0839-5.
Int J Clin Pract. 2013 Jan;67(1):14-31. doi: 10.1111/j.1742-1241.2012.02954.x. Epub 2012 Jul 11.
4
New insights into uric acid effects on the progression and prognosis of chronic kidney disease.尿酸对慢性肾脏病进展和预后影响的新认识。
Ren Fail. 2012;34(4):510-20. doi: 10.3109/0886022X.2011.653753. Epub 2012 Jan 20.
5
Relationship between hyperuricemia and chronic kidney disease.高尿酸血症与慢性肾脏病的关系。
Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1039-44. doi: 10.1080/15257770.2011.611484.
6
Effects of lipid-lowering therapy with rosuvastatin on kidney function and oxidative stress in patients with diabetic nephropathy.瑞舒伐他汀降脂治疗对糖尿病肾病患者肾功能和氧化应激的影响。
J Atheroscler Thromb. 2011;18(11):1018-28. doi: 10.5551/jat.9084. Epub 2011 Sep 15.
7
Endothelium-derived endothelin-1.内皮细胞衍生的内皮素-1。
Pflugers Arch. 2010 May;459(6):951-8. doi: 10.1007/s00424-009-0763-y. Epub 2009 Dec 5.
8
The role of hyperuricemia in vascular disorders.高尿酸血症在血管疾病中的作用。
Curr Opin Rheumatol. 2009 Mar;21(2):132-7. doi: 10.1097/BOR.0b013e3283257b96.
9
Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells.尿酸可降低培养的肺动脉内皮细胞中一氧化氮的生成，并增加精氨酸酶活性。
Am J Physiol Cell Physiol. 2008 Nov;295(5):C1183-90. doi: 10.1152/ajpcell.00075.2008. Epub 2008 Sep 10.
10
Inactivation of nitric oxide by uric acid.尿酸对一氧化氮的灭活作用。
Nucleosides Nucleotides Nucleic Acids. 2008 Aug;27(8):967-78. doi: 10.1080/15257770802257952.