Berghuis Sietske A, Soechitram Shalini D, Hitzert Marrit M, Sauer Pieter J J, Bos Arend F
Beatrix Children's Hospital, Department of Pediatrics, Division of Neonatology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Neurotoxicology. 2013 Sep;38:124-30. doi: 10.1016/j.neuro.2013.07.003. Epub 2013 Jul 27.
Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that are potentially toxic to the developing brain. Hydroxylated metabolites of PCBs (OH-PCBs) are suggested to be even more toxic. Little is known about their short-term effects on human health.
To determine whether prenatal background exposure to PCBs and OH-PCBs was associated with the motor development of three-month-old infants.
Ninety-seven mother-infant pairs participated in this Dutch, observational cohort study. We determined the concentrations of PCBs and OH-PCBs in cord blood samples. When the infants were three months old we evaluated their motor development by assessing the presence and performance of spontaneous movement patterns from video recordings. We calculated a Motor Optimality Score (MOS). The score could range from low (5) to high (28) optimality. We explored the correlations between PCB and OH-PCB levels and MOS. Subsequently, we tested whether the levels differed between infants with a low (<26) or high (≥26) MOS and whether the levels associated with detailed aspects of their motor repertoires.
We found several associations between PCB and OH-PCB levels and MOS, including detailed aspects of the early motor development. High 4-OH-PCB-107 levels were associated with a low MOS (P=.013). High PCB-187 levels were associated with reduced midline arm and leg movements (P=.047 and P=.043, respectively). High 4'-OH-PCB-172 levels were associated with more manipulation (P=.033).
Prenatal exposure to high background levels of most PCBs and 4-OH-PCB-107 seems to impair early motor development, whereas only 4'-OH-PCB-172 showed the opposite.
多氯联苯（PCBs）是普遍存在的环境污染物，对发育中的大脑具有潜在毒性。多氯联苯的羟基化代谢物（OH-PCBs）被认为毒性更强。关于它们对人类健康的短期影响知之甚少。
确定产前PCBs和OH-PCBs的背景暴露是否与三个月大婴儿的运动发育有关。
97对母婴参与了这项荷兰的观察性队列研究。我们测定了脐带血样本中PCBs和OH-PCBs的浓度。当婴儿三个月大时，我们通过评估视频记录中自发运动模式的存在和表现来评估他们的运动发育。我们计算了运动最优性评分（MOS）。该评分范围从低（5）到高（28）最优性。我们探讨了PCBs和OH-PCBs水平与MOS之间的相关性。随后，我们测试了MOS低（<26）或高（≥26）的婴儿之间的水平是否存在差异，以及这些水平是否与他们运动技能的详细方面相关。
我们发现PCBs和OH-PCBs水平与MOS之间存在多种关联，包括早期运动发育的详细方面。4-OH-PCB-107水平高与低MOS相关（P = 0.013）。PCB-187水平高与中线手臂和腿部运动减少相关（分别为P = 0.047和P = 0.043）。4'-OH-PCB-172水平高与更多的操作相关（P = 0.033）。
产前暴露于大多数PCBs和4-OH-PCB-107的高背景水平似乎会损害早期运动发育，而只有4'-OH-PCB-172表现出相反的情况。
