克霉唑可抑制阴道炎症和中性粒细胞浸润对白念珠菌感染的反应。
Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.
机构信息
Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.
出版信息
Antimicrob Agents Chemother. 2013 Oct;57(10):5178-80. doi: 10.1128/AAC.01244-13. Epub 2013 Jul 29.
Abstract
The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.
摘要
外阴阴道假丝酵母菌病（VVC）的病理学与非保护性炎症反应有关，通常用克霉唑治疗。我们研究了克霉唑解决 VVC 的机制。低水平的克霉唑（不会阻止真菌生长）抑制“危险反应”转录因子 c-Fos 的表达，阻断促炎细胞因子的产生，并抑制中性粒细胞浸润感染部位。
相似文献
1
Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.克霉唑可抑制阴道炎症和中性粒细胞浸润对白念珠菌感染的反应。
Antimicrob Agents Chemother. 2013 Oct;57(10):5178-80. doi: 10.1128/AAC.01244-13. Epub 2013 Jul 29.
2
Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial.蜂蜜与克霉唑阴道软膏治疗外阴阴道假丝酵母菌病的疗效比较：一项随机临床试验。
J Mycol Med. 2017 Dec;27(4):494-500. doi: 10.1016/j.mycmed.2017.07.003. Epub 2017 Jul 29.
3
Genotyping and Persistence of Candida albicans from Pregnant Women with Vulvovaginal Candidiasis.孕妇外阴阴道假丝酵母菌病中白色念珠菌的基因分型与持续存在。
Mycopathologia. 2017 Apr;182(3-4):339-347. doi: 10.1007/s11046-016-0095-3. Epub 2016 Nov 23.
4
Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase and morphology.克霉唑对白色念珠菌的抗真菌活性取决于碳源、生长阶段和形态。
J Med Microbiol. 2015 Jul;64(7):714-723. doi: 10.1099/jmm.0.000082. Epub 2015 May 14.
5
Comparative analysis of two immunosuppression protocols for vulvovaginal candidiasis induction in Wistar rats.两种免疫抑制方案诱导Wistar大鼠外阴阴道念珠菌病的比较分析
Braz J Microbiol. 2025 Jun;56(2):1117-1129. doi: 10.1007/s42770-025-01661-6. Epub 2025 Apr 4.
6
n-butanol extract of Pulsatilla decoction alleviates vulvovaginal candidiasis via the regulation of mitochondria-associated Type I interferon signaling pathways.白头翁汤正丁醇提取物通过调节线粒体相关的I型干扰素信号通路减轻外阴阴道念珠菌病。
J Ethnopharmacol. 2025 Jan 31;340:119292. doi: 10.1016/j.jep.2024.119292. Epub 2024 Dec 26.
7
[Analysis of resistance and sensitivity of 1 200 strains of vulvovaginal candidiasis in China to five common antifungal drugs].[中国1200株外阴阴道假丝酵母菌病对5种常用抗真菌药物的耐药性及敏感性分析]
Zhonghua Fu Chan Ke Za Zhi. 2022 Aug 25;57(8):601-607. doi: 10.3760/cma.j.cn112141-20220211-00076.
8
Clotrimazole-induced shifts in vaginal bacteriome and lipid metabolism: insights into recovery mechanisms in vulvovaginal candidiasis.克霉唑引起的阴道微生物群和脂质代谢变化：对外阴阴道念珠菌病恢复机制的见解
J Appl Microbiol. 2024 Nov 4;135(11). doi: 10.1093/jambio/lxae269.
9
[Comparison of the effectiveness of nystatin and kanesten in the treatment of vulvovaginal candidiasis].[制霉菌素与克霉唑治疗外阴阴道念珠菌病的疗效比较]
Wiad Lek. 1981 Apr 15;34(8):663-5.
10
Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa.白色念珠菌溶血素驱动阴道黏膜上皮信号转导、中性粒细胞募集和免疫病理学过程。
Infect Immun. 2018 Jan 22;86(2). doi: 10.1128/IAI.00645-17. Print 2018 Feb.
引用本文的文献
1
Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane.克霉唑使磷脂双分子层流化，并定位于靠近膜极性部分的疏水区。
Biomolecules. 2021 Sep 2;11(9):1304. doi: 10.3390/biom11091304.
2
Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.囊性纤维化中性粒细胞钙稳态失调导致抗菌反应缺陷。
J Immunol. 2018 Oct 1;201(7):2016-2027. doi: 10.4049/jimmunol.1800076. Epub 2018 Aug 17.
本文引用的文献
1
Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress.白色念珠菌细胞对吞噬作用和中性粒细胞细胞外活性的反应对于抵抗碳水化合物饥饿、氧化和硝化应激至关重要。
PLoS One. 2012;7(12):e52850. doi: 10.1371/journal.pone.0052850. Epub 2012 Dec 21.
2
Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins.宿主对白念珠菌阴道炎反应中的细胞因子：鉴定非经典免疫介质 S100 警报素的作用。
Cytokine. 2012 Apr;58(1):118-28. doi: 10.1016/j.cyto.2011.11.021. Epub 2011 Dec 17.
3
Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.白色念珠菌酵母相和菌丝相通过 MAPK 信号通路在阴道上皮细胞中被区分。
PLoS One. 2011;6(11):e26580. doi: 10.1371/journal.pone.0026580. Epub 2011 Nov 8.
4
Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.白色念珠菌对阴道上皮细胞的黏附、侵袭和损伤：克霉唑和联苯苄唑的阶段特异性抑制。
Antimicrob Agents Chemother. 2011 Sep;55(9):4436-9. doi: 10.1128/AAC.00144-11. Epub 2011 Jul 11.
5
From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells.从黏附到损伤：白念珠菌的明确基因在与口腔上皮细胞相互作用过程中介导黏附、侵袭和损伤。
PLoS One. 2011 Feb 23;6(2):e17046. doi: 10.1371/journal.pone.0017046.
6
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells.双相固有免疫 MAPK 反应可区分上皮细胞中白色念珠菌的酵母和菌丝形式。
Cell Host Microbe. 2010 Sep 16;8(3):225-35. doi: 10.1016/j.chom.2010.08.002.
7
Epithelial cell-derived S100 calcium-binding proteins as key mediators in the hallmark acute neutrophil response during Candida vaginitis.上皮细胞衍生的 S100 钙结合蛋白作为念珠菌性阴道炎中性粒细胞急性反应特征中的关键介质。
Infect Immun. 2010 Dec;78(12):5126-37. doi: 10.1128/IAI.00388-10. Epub 2010 Sep 7.
8
Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-kappaB-dependent manner.克霉唑通过核因子κB依赖性方式抑制白细胞介素-8表达，从而改善肠道炎症和异常血管生成。
J Pharmacol Exp Ther. 2008 Nov;327(2):353-64. doi: 10.1124/jpet.108.141887. Epub 2008 Aug 26.
9
Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils.ERK激酶信号传导的诱导引发人类中性粒细胞对白色念珠菌菌丝体的形态型特异性杀伤。
Cell Microbiol. 2008 Mar;10(3):807-20. doi: 10.1111/j.1462-5822.2007.01086.x. Epub 2007 Nov 21.
10
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.人类上皮细胞通过Toll样受体4（TLR4）介导的信号传导建立直接的抗真菌防御。
J Clin Invest. 2007 Dec;117(12):3664-72. doi: 10.1172/JCI28115.
Zotero 插件