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克霉唑可抑制阴道炎症和中性粒细胞浸润对白念珠菌感染的反应。

Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.

机构信息

Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany.

出版信息

Antimicrob Agents Chemother. 2013 Oct;57(10):5178-80. doi: 10.1128/AAC.01244-13. Epub 2013 Jul 29.

DOI:10.1128/AAC.01244-13
PMID:23896471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3811401/
Abstract

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

摘要

外阴阴道假丝酵母菌病（VVC）的病理学与非保护性炎症反应有关，通常用克霉唑治疗。我们研究了克霉唑解决 VVC 的机制。低水平的克霉唑（不会阻止真菌生长）抑制“危险反应”转录因子 c-Fos 的表达，阻断促炎细胞因子的产生，并抑制中性粒细胞浸润感染部位。

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本文引用的文献

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PLoS One. 2012;7(12):e52850. doi: 10.1371/journal.pone.0052850. Epub 2012 Dec 21.
2
Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins.宿主对白念珠菌阴道炎反应中的细胞因子：鉴定非经典免疫介质 S100 警报素的作用。
Cytokine. 2012 Apr;58(1):118-28. doi: 10.1016/j.cyto.2011.11.021. Epub 2011 Dec 17.
3
Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.白色念珠菌酵母相和菌丝相通过 MAPK 信号通路在阴道上皮细胞中被区分。
PLoS One. 2011;6(11):e26580. doi: 10.1371/journal.pone.0026580. Epub 2011 Nov 8.
4
Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.白色念珠菌对阴道上皮细胞的黏附、侵袭和损伤：克霉唑和联苯苄唑的阶段特异性抑制。
Antimicrob Agents Chemother. 2011 Sep;55(9):4436-9. doi: 10.1128/AAC.00144-11. Epub 2011 Jul 11.
5
From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells.从黏附到损伤：白念珠菌的明确基因在与口腔上皮细胞相互作用过程中介导黏附、侵袭和损伤。
PLoS One. 2011 Feb 23;6(2):e17046. doi: 10.1371/journal.pone.0017046.
6
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells.双相固有免疫 MAPK 反应可区分上皮细胞中白色念珠菌的酵母和菌丝形式。
Cell Host Microbe. 2010 Sep 16;8(3):225-35. doi: 10.1016/j.chom.2010.08.002.
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Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils.ERK激酶信号传导的诱导引发人类中性粒细胞对白色念珠菌菌丝体的形态型特异性杀伤。
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Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.人类上皮细胞通过Toll样受体4（TLR4）介导的信号传导建立直接的抗真菌防御。
J Clin Invest. 2007 Dec;117(12):3664-72. doi: 10.1172/JCI28115.