白色念珠菌对阴道上皮细胞的黏附、侵袭和损伤：克霉唑和联苯苄唑的阶段特异性抑制。
Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.
机构信息
Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute Jena (HKI), Beutenbergstraße 11a, D-07745 Jena, Germany.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4436-9. doi: 10.1128/AAC.00144-11. Epub 2011 Jul 11.
Abstract
Clotrimazole and bifonazole are highly effective antifungal agents against mucosal Candida albicans infections. Here we examined the effects of low levels of clotrimazole and bifonazole on the ability of C. albicans to adhere, invade, and damage vaginal epithelial cells. Although adhesion and invasion were not affected, damage was greatly reduced upon azole treatment. This clearly indicates that low levels of azoles influence specific activities of C. albicans during distinct stages of vaginal epithelium infections.
摘要
克霉唑和联苯苄唑是治疗黏膜白色念珠菌感染的高效抗真菌药物。本研究旨在探讨低浓度克霉唑和联苯苄唑对白色念珠菌黏附、侵袭和破坏阴道上皮细胞能力的影响。结果发现，唑类药物处理后，白色念珠菌的黏附和侵袭能力并未受到影响，但对其破坏能力有明显抑制作用。这表明低浓度唑类药物可能通过影响白色念珠菌在阴道上皮感染不同阶段的特定活性，发挥其抗真菌作用。
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