Arendt-Nielsen L, Kaalund S, Bjerring P, Høgsaa B
Department of Medical Informatics, Aalborg University, Denmark.
Acta Anaesthesiol Scand. 1990 Jul;34(5):358-61. doi: 10.1111/j.1399-6576.1990.tb03103.x.
The analgesic effects of intradermal lidocaine infiltration and topical EMLA cream applications (eutectic mixture of local anaesthetics) were studied in 8 patients with Ehlers Danlos syndrome type III, a heritable disorder of connective tissue, and in 8 controls. Cutaneous analgesia was evaluated by sensory and pain thresholds to short argon laser stimulation, and the depth of cutaneous analgesia was measured by sensory and pain thresholds to controlled needle insertion. Five minutes after lidocaine infiltration, the laser-induced pain was abolished in both groups, but 1 h later only the skin of the controls remained analgesic. EMLA cream was applied for 30, 60, and 120 min, but none of the patients obtained sufficient analgesia. Full analgesia was obtained for the controls after 60 and 120 min of application. The depth of cutaneous EMLA analgesia was significantly less for the patients compared to controls. The present quantitative findings support clinical observations that long-lasting cutaneous analgesia is difficult to obtain for this group of patients.
对8名患有III型埃勒斯-当洛综合征（一种遗传性结缔组织疾病）的患者和8名对照者，研究了皮内注射利多卡因浸润和外用EMLA乳膏（局部麻醉药的共熔混合物）的镇痛效果。通过对短脉冲氩激光刺激的感觉阈值和疼痛阈值来评估皮肤镇痛情况，通过对控制下的针刺的感觉阈值和疼痛阈值来测量皮肤镇痛的深度。利多卡因浸润5分钟后，两组患者的激光诱发疼痛均消失，但1小时后只有对照组的皮肤仍保持镇痛。分别涂抹EMLA乳膏30、60和120分钟，但没有一名患者获得足够的镇痛效果。对照组在涂抹60和120分钟后获得了完全镇痛效果。与对照组相比，患者的皮肤EMLA镇痛深度明显较浅。目前的定量研究结果支持临床观察，即该组患者很难获得持久的皮肤镇痛效果。
