Arendt-Nielsen L, Kaalund S, Høgsaa B, Bjerring P, Grevy C
Dept. of Medical Informatics, Aalborg University, Denmark.
Scand J Rheumatol. 1991;20(3):190-5. doi: 10.3109/03009749109103020.
To make a differential diagnosis of Ehlers Danlos (EDS) Type III syndrome and Hypermobile patients has been difficult. In genetic advising and prognosis of the EDS patients there are need for new tools to separate them from hypermobile patients. Topical analgesics (EMLA cream) was applied to seven EDS patients, ten hypermobile patients, and to fifteen controls. The analgesic efficacy of cutaneous analgesia was evaluated by sensory and pain thresholds to brief argon laser stimuli, and the depth of the cutaneous analgesia was measured by sensory and pain threshold depth to controlled needle insertions. Controls and hypermobiles did not differ in their response to cutaneous analgesia. The thresholds to cutaneous laser stimulation and the depth of analgesia increased significantly less in the Ehlers Danlos patients compared to the other two groups. In clinical practice a needle insertion test can easily be applied to investigate if patients are responders or non-responders to local analgesics.
对埃勒斯-当洛综合征（EDS）Ⅲ型患者和关节活动过度患者进行鉴别诊断一直很困难。在EDS患者的遗传咨询和预后评估中，需要新的工具来将他们与关节活动过度患者区分开来。对7名EDS患者、10名关节活动过度患者和15名对照组患者使用了局部镇痛药（复方利多卡因乳膏）。通过对短暂氩激光刺激的感觉阈值和疼痛阈值来评估皮肤镇痛的镇痛效果，并通过对可控针刺的感觉阈值深度和疼痛阈值深度来测量皮肤镇痛的深度。对照组和关节活动过度患者对皮肤镇痛的反应没有差异。与其他两组相比，埃勒斯-当洛患者对皮肤激光刺激的阈值和镇痛深度的增加明显较少。在临床实践中，可以很容易地应用针刺试验来调查患者对局部镇痛药是有反应还是无反应。
