多梳蛋白家族和 MYC：癌症的关联。
Polycomb group proteins and MYC: the cancer connection.
机构信息
Blood Bank, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece,
出版信息
Cell Mol Life Sci. 2014 Jan;71(2):257-69. doi: 10.1007/s00018-013-1426-x. Epub 2013 Jul 30.
Abstract
Polycomb group proteins (PcGs) are transcriptional repressors involved in physiological processes whereas PcG deregulation might result in oncogenesis. MYC oncogene is able to regulate gene transcription, proliferation, apoptosis, and malignant transformation. MYC deregulation might result in tumorigenesis with tumor maintenance properties in both solid and blood cancers. Although the interaction of PcG and MYC in cancer was described years ago, new findings are reported every day to explain the exact mechanisms and results of such interactions. In this review, we summarize recent data on the PcG and MYC interactions in cancer, and the putative involvement of microRNAs in the equation.
摘要
多梳抑制复合物蛋白（PcG）是参与生理过程的转录抑制因子，而 PcG 的失调可能导致肿瘤发生。MYC 癌基因能够调节基因转录、增殖、凋亡和恶性转化。MYC 的失调可能导致肿瘤发生，并具有实体瘤和血液癌中的肿瘤维持特性。尽管 PcG 和 MYC 在癌症中的相互作用多年前就已被描述，但每天都有新的发现来解释这种相互作用的确切机制和结果。在这篇综述中，我们总结了最近关于癌症中 PcG 和 MYC 相互作用的研究数据，以及 microRNAs 在其中的可能参与。
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