Gholami Ali, Farhadi Khosro, Sayyadipour Fatemeh, Soleimani Masoud, Saba Fakhredin
Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran.
Department of Haematology, Tarbiat Modares University, Tehran 146899-5513, Iran.
Genes Dis. 2021 Feb 12;9(4):900-914. doi: 10.1016/j.gendis.2021.02.001. eCollection 2022 Jul.
Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize the current knowledge on lncRNAs involved in lymphomas, their molecular functions, as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis, cell proliferation, invasion, and response to chemotherapy. The expression level of lncRNAs can affect chemotherapy-induced apoptosis. Taken together, lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells.
淋巴瘤是一组多样的血液系统恶性肿瘤，发生于淋巴系统的抗感染细胞中。长链非编码RNA（lncRNA）是非编码RNA，最近作为基因表达的主要调节因子受到了广泛关注。在本综述中，我们总结了目前关于lncRNA参与淋巴瘤的相关知识、它们的分子功能以及潜在的临床价值。通过使用以下关键词在PubMed上搜索英文文献来确定相关文献：淋巴瘤、lncRNA、白血病、增殖、凋亡和预后。lncRNA通过影响凋亡、细胞增殖、侵袭以及对化疗的反应，对淋巴瘤的发生发展至关重要。lncRNA的表达水平可影响化疗诱导的凋亡。综上所述，淋巴瘤细胞中lncRNA的失调不仅是一种附带现象，而且lncRNA转录与淋巴瘤的发生和发展密切相关。lncRNA的异常表达可导致正常淋巴细胞转化为淋巴瘤细胞。
