Osaka City University Graduate School of Medicine, Department of Surgical Oncology, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Japan.
Anticancer Res. 2013 Aug;33(8):3291-4.
Previous studies have reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with a poor prognosis in patients with various types of cancers. The aim of this study was to determine the prognostic significance of preoperative NLR in patients with colorectal cancer and to determine an appropriate cut-off value of the NLR.
We enrolled 674 patients who underwent surgery for stage I-IV colorectal cancer. The mean NLR was 2.74±2.20. To determine the appropriate cut-off value of the NLR, we used a receiver operating characteristic curve. A total of 262 patients with an NLR of 2.5 or more were classified as high-NLR individuals in this study. The prognostic significance of a high NLR was evaluated using a multivariate analysis.
The cancer-specific survival was significantly (p<0.001) worse in the patients with a high NLR. The multivariate analysis indicated that the tumor diameter, the presence of lymph node or distant metastasis, and a high NLR were independent risk factors for poor survival.
Preoperative NLR measurement is a convenient biomarker and predictor of a poor prognosis after surgery for colorectal cancer.
先前的研究报告称，术前中性粒细胞与淋巴细胞比值（NLR）升高与各种类型癌症患者的预后不良有关。本研究旨在确定术前 NLR 在结直肠癌患者中的预后意义，并确定 NLR 的适当临界值。
我们纳入了 674 例接受 I-IV 期结直肠癌手术的患者。平均 NLR 为 2.74±2.20。为了确定 NLR 的适当临界值，我们使用了受试者工作特征曲线。在本研究中，将 NLR 为 2.5 或更高的 262 例患者归类为高 NLR 个体。使用多变量分析评估高 NLR 的预后意义。
高 NLR 患者的癌症特异性生存率显著（p<0.001）较差。多变量分析表明，肿瘤直径、淋巴结或远处转移的存在以及高 NLR 是生存不良的独立危险因素。
术前 NLR 测量是结直肠癌手术后预后不良的一种方便的生物标志物和预测指标。
