Brumbaugh G W, Benson P A
Department of Large Animal Medicine, Texas Veterinary Medical Center, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Am J Vet Res. 1990 Jul;51(7):1032-7.
Samples of pleural fluid from 20 horses with effusive pleural diseases of various causes were evaluated; samples from 19 horses were used for the study. There were differences for pH (P = 0.001) and partial pressure of oxygen (PO2) between arterial blood and nonseptic pleural fluid (P = 0.0491), but there were no differences for pH, PO2, partial pressure of carbon dioxide (PCO2), and concentrations of bicarbonate (HCO3-), lactate, and glucose between venous blood and nonseptic pleural fluid. Paired comparisons of venous blood and nonseptic pleural fluid from the same horse indicated no differences. There were differences (P = 0.0001, each) for pH, PO2, PCO2, and concentrations of HCO3- between arterial blood and septic pleural fluid. Differences also existed for pH (P = 0.0001), PCO2 (P = 0.0003), and concentrations of HCO3- (P = 0.0001), lactate (P = 0.0051), and glucose (P = 0.0001) between venous blood and septic pleural fluid. Difference was not found for values of PO2 between venous blood and septic pleural fluid, although 4 samples of septic pleural fluid contained virtually no oxygen. Paired comparisons of venous blood and septic pleural fluid from the same horse revealed differences (P less than 0.05) for all values, except those for PO2. These alterations suggested functional and physical compartmentalization that separated septic and healthy tissue. Compartmentalization and microenvironmental factors at the site of infection should be considered when developing therapeutic strategies for horses with septic pleural disease.
对20匹患有各种病因所致渗出性胸膜疾病的马的胸水样本进行了评估；其中19匹马的样本用于本研究。动脉血与非感染性胸水之间的pH值（P = 0.001）和氧分压（PO2）存在差异（P = 0.0491），但静脉血与非感染性胸水之间的pH值、PO2、二氧化碳分压（PCO2）以及碳酸氢盐（HCO3-）、乳酸盐和葡萄糖浓度无差异。同一匹马的静脉血与非感染性胸水的配对比较显示无差异。动脉血与感染性胸水之间的pH值、PO2、PCO2以及HCO3-浓度存在差异（均为P = 0.0001）。静脉血与感染性胸水之间的pH值（P = 0.0001）、PCO2（P = 0.0003）以及HCO3-浓度（P = 0.0001）、乳酸盐（P = 0.0051）和葡萄糖（P = 0.0001）也存在差异。静脉血与感染性胸水之间的PO2值未发现差异，尽管4份感染性胸水样本几乎不含氧。同一匹马的静脉血与感染性胸水的配对比较显示，除PO2外，所有值均存在差异（P < 0.05）。这些改变提示存在将感染组织与健康组织分隔开的功能和物理分隔。在为患有感染性胸膜疾病的马制定治疗策略时，应考虑感染部位的分隔和微环境因素。
