Tappin S W, Ferrandis I, Jakovljevic S, Villiers E, White R A S
Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Suffolk, CB8 0UH.
J Small Anim Pract. 2012 Nov;53(11):657-60. doi: 10.1111/j.1748-5827.2012.01268.x.
A six-year-old female entire German shepherd dog was investigated for polyuria, polydipsia and lethargy. Investigations revealed a mild azotaemia and abdominal ultrasound revealed marked bilateral dilation of the renal pelves with echogenic material and proximal left hydroureter. Urine cytological examination and aspirates from the right renal pelvis revealed mats of fungal hyphae consistent with fungal bezoar formation. Fungal cultures revealed a profuse growth of Paecilomyces variotii. Initial treatment with oral itraconazole was unsuccessful, leading to bilateral nephrotomies to remove the fungal material. Postoperatively the Paecilomyces infection persisted despite continued itraconazole therapy. Treatment was commenced with amphotericin B, leading to resolution of the dog's clinical signs. To the authors' knowledge this is the first report of canine Paecilomyces pyelonephritis, without disseminated systemic disease, which documents its successful treatment.
一只六岁未绝育的雌性德国牧羊犬因多尿、多饮和嗜睡接受检查。检查发现有轻度氮血症，腹部超声显示双侧肾盂明显扩张，有回声物质，左侧输尿管上段积水。尿液细胞学检查以及右肾盂抽吸物显示有真菌菌丝团，符合真菌粪石形成。真菌培养显示拟青霉大量生长。最初口服伊曲康唑治疗未成功，导致进行双侧肾切开术以清除真菌物质。术后，尽管继续使用伊曲康唑治疗，拟青霉感染仍持续存在。开始用两性霉素B治疗，使犬的临床症状得到缓解。据作者所知，这是第一例无播散性全身疾病的犬拟青霉肾盂肾炎报告，并记录了其成功治疗的情况。
