Armentano Robert A, Cooke Kirsten L, Wickes Brian L
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
J Am Vet Med Assoc. 2013 Feb 1;242(3):381-7. doi: 10.2460/javma.242.3.381.
A 5-year-old 34.3-kg (75.5-lb) neutered male German Shepherd Dog was evaluated because of chronic azotemia that was unresponsive to typical medical management.
Urinalysis revealed pyuria and fungal hyphae. Fungal culture of a urine sample grew a sterile mold that was identified as Westerdykella spp via PCR assay. TREATMENT AND OUTCOME-: he dog was treated empirically with itraconazole orally and amphotericin B IV for 5 weeks. Because of progressive azotemia, treatment was modified to oral administration of posaconazole. The dog improved but then developed progressive azotemia, hyperphosphatemia, and suspected diskospondylitis. Treatment was again modified to oral administration of terbinafine on the basis of results of antifungal susceptibility testing. The dog was euthanized after 5 months of antifungal treatment because of a deteriorating clinical condition and progressive azotemia.
Westerdykella spp are filamentous hyphal organisms from the family Sporomiaceae and had not previously been reported to cause infections in dogs. Fungal PCR assay and antifungal susceptibility testing may be useful for a patient with a suspected fungal infection that does not respond to empirical treatment or when traditional culture methods for fungal identification are unsuccessful. Westerdykella spp should be considered as a possible etiologic agent when systemic mycosis is diagnosed.
一只5岁、体重34.3千克（75.5磅）已绝育的雄性德国牧羊犬因慢性氮血症接受评估，该病症对典型的药物治疗无反应。
尿液分析显示有脓尿和真菌菌丝。尿液样本的真菌培养长出一种无菌霉菌，通过聚合酶链反应检测鉴定为韦斯特德氏菌属。治疗与结果：该犬经验性地接受口服伊曲康唑和静脉注射两性霉素B治疗5周。由于氮血症进展，治疗改为口服泊沙康唑。犬的病情有所改善，但随后出现进行性氮血症、高磷血症和疑似椎间盘炎。根据抗真菌药敏试验结果，治疗再次改为口服特比萘芬。在抗真菌治疗5个月后，由于临床状况恶化和进行性氮血症，该犬实施安乐死。
韦斯特德氏菌属是来自孢子菌科的丝状菌丝生物体，此前尚未报道其可引起犬类感染。对于疑似真菌感染但对经验性治疗无反应或传统真菌鉴定培养方法不成功的患者，真菌聚合酶链反应检测和抗真菌药敏试验可能有用。诊断全身性真菌病时，应将韦斯特德氏菌属视为可能的病原体。
