Takizawa K, Harada M, Fujimaru J, Shima Y, Yokoo I, Ozaki I, Sato M, Iguchi T, Takeda Y
Dept. of Obstetrics & Gynecology, Tokyo Women's Medical College.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1569-74.
Two-route chemotherapy of CDDP and STS was performed in 16 postoperative patients with ovarian cancer under the hypertensive condition of 20 minutes induced with angiotensin II (AT-II). Plasma total CDDP and filtrable CDDP levels serially determined at 15 and 30 minutes after intraperitoneal administration of CDDP (150 mg/body) were significantly higher than under the same condition except for using AT-II. The extreme vasoconstriction in the kidney and other organs during AT-II induced hypertension would protect these organs from CDDP induced toxicities. Furthermore, STS infused immediately after the cessation of AT-II could neutralize the CDDP preventing the occurrence of toxicities. The elevating plasma levels of CDDP might be beneficial to enhance the anticancer effects of CDDP, since the blood flow in cancer tissue was increased during AT-II induced hypertension.
对16例卵巢癌术后患者进行顺铂（CDDP）和丝裂霉素（STS）双途径化疗，在使用血管紧张素II（AT-II）诱导的20分钟高血压状态下进行。腹腔注射CDDP（150mg/体）后15分钟和30分钟连续测定的血浆总CDDP和可滤过CDDP水平显著高于不使用AT-II的相同条件下。AT-II诱导高血压期间肾脏和其他器官的极度血管收缩可保护这些器官免受CDDP诱导的毒性。此外，在AT-II停止后立即输注STS可中和CDDP，防止毒性发生。CDDP血浆水平升高可能有利于增强CDDP的抗癌作用，因为AT-II诱导高血压期间癌组织中的血流增加。
