Aktas Sinem, Basoglu Mehmet Sinan, Aslan Hale, Ilknur Ali Ekber, Dundar Riza, Katilmis Huseyin, Ozturkcan Sedat
Department of Otorhinolaryngology and Head and Neck Surgery, İzmir Private Su Hospital, İzmir, Turkey.
Int J Pediatr Otorhinolaryngol. 2013 Sep;77(9):1465-8. doi: 10.1016/j.ijporl.2013.06.010. Epub 2013 Jul 27.
To investigate the ototoxic effect of boric acid solution prepared with different degree of alcohol.
This study was performed on 28 young albino guinea pigs. After the animals divided four groups prior to the application of the solution an auditory brainstem response (ABR) test was applied to the each animal under general anesthesia. Their tympanic membranes perforated and test solutions were administrated to the middle ear through the perforation. On 15th day, ABR measurements were carried out and comparison was made with preadministration values.
The degrees of hearing loss occurring as a result of the administration of 4% boric alcohol solutions prepared with 60° and 40° alcohol differed significantly (p < 0.001).
It was established that 4% boric acid solution prepared with 60 alcohol affected hearing in guinea pigs more negatively and an increase in degree of alcohol also increased the ototoxicity of the boric acid solution.
研究用不同酒精浓度配制的硼酸溶液的耳毒性作用。
本研究以28只幼年白化豚鼠为对象。动物分组后，在溶液应用前，对每只动物在全身麻醉下进行听性脑干反应（ABR）测试。将它们的鼓膜穿孔，通过穿孔将测试溶液注入中耳。在第15天，进行ABR测量，并与给药前的值进行比较。
用60°和40°酒精配制的4%硼酸酒精溶液给药后出现的听力损失程度有显著差异（p < 0.001）。
已证实用60度酒精配制的4%硼酸溶液对豚鼠听力的负面影响更大，酒精浓度的增加也会增加硼酸溶液的耳毒性。
