Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey.
Med Princ Pract. 2013;22(5):475-9. doi: 10.1159/000351572. Epub 2013 Jul 26.
To investigate the renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with polycystic ovarian syndrome (PCOS).
In this case-control study, 41 obese (PCOS) women and 29 healthy controls, matched for age and body mass index, were enrolled. Anthropometric, metabolic, and hormonal patterns, including plasma aldosterone, plasma renin, and ACE activity, were measured in each subject.
Plasma renin levels were significantly higher in PCOS patients (19.7 ± 14.5 µg/ml) compared with controls (12.9 ± 9.0 µg/ml, p < 0.05). ACE activity and aldosterone levels did not significantly differ between both groups (p = 0.15 and p = 0.18, respectively). Analysis of PCOS patients showed a significant correlation of fasting insulin levels with levels of renin (r = 0.305, p < 0.01) and free testosterone (r = 0.384, p = 0.001). Similarly, homeostasis model assessment index was positively correlated with total renin concentrations (r = 0.366, p < 0.01) and free testosterone (r = 0.352, p < 0.01).
Obese PCOS women had higher total renin levels, but not ACE activity and aldosterone levels, related to insulin resistance compared with controls.
研究多囊卵巢综合征（PCOS）患者的肾素-血管紧张素-醛固酮系统和血管紧张素转换酶（ACE）活性。
在这项病例对照研究中，纳入了 41 名肥胖（PCOS）女性和 29 名年龄和体重指数匹配的健康对照者。测量了每位受试者的人体测量学、代谢和激素模式，包括血浆醛固酮、血浆肾素和 ACE 活性。
与对照组（12.9 ± 9.0 µg/ml，p < 0.05）相比，PCOS 患者的血浆肾素水平明显更高（19.7 ± 14.5 µg/ml）。ACE 活性和醛固酮水平在两组之间无显著差异（p = 0.15 和 p = 0.18，分别）。对 PCOS 患者的分析显示，空腹胰岛素水平与肾素（r = 0.305，p < 0.01）和游离睾酮（r = 0.384，p = 0.001）水平呈显著相关。同样，稳态模型评估指数与总肾素浓度（r = 0.366，p < 0.01）和游离睾酮（r = 0.352，p < 0.01）呈正相关。
与对照组相比，肥胖的 PCOS 女性的总肾素水平更高，但 ACE 活性和醛固酮水平没有变化，与胰岛素抵抗有关。
