Bello Cristina, Mondaca-Cornejo Luis, Navarrete-Dechent Cristian, González Sergio
Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Rev Med Chil. 2013 Apr;141(4):525-30. doi: 10.4067/S0034-98872013000400015.
Pemphigus is an autoimmune bullous disease that involves skin and mucous membranes caused by autoantibodies against antigens on the surface of keratinocytes. We report a 30-year-old mole presenting with a five months history of pruriginous alopecic and crusted lesions in the scalp, that extended posteriorly to the trunk and limbs. Mucous membranes were not involved. A skin biopsy was performed, showing extensive loss of epidermis and acantholysis. Immuno fluorescence was positive for C3 and intercellular and epidermic IgG. With the presumptive diagnosis of pemphigus vulgaris (PV) without mucous involvement, the patient was treated with prednisone, observing an excellent clinical response. There are only few cases published in the literature of PV without mucous involvement. Some authors refer to this subtype of PV as "Cutaneous pemphigus vulgaris".
天疱疮是一种自身免疫性大疱性疾病，由针对角质形成细胞表面抗原的自身抗体引起，累及皮肤和黏膜。我们报告一例30岁患者，头皮出现瘙痒性脱发和结痂性皮损5个月，皮损向后扩展至躯干和四肢。未累及黏膜。进行了皮肤活检，显示表皮广泛缺失和棘层松解。免疫荧光显示C3以及细胞间和表皮IgG呈阳性。初步诊断为无黏膜受累的寻常型天疱疮（PV），患者接受泼尼松治疗，临床反应良好。文献中仅有少数无黏膜受累的PV病例报道。一些作者将这种PV亚型称为“皮肤寻常型天疱疮”。
