Rahamon Sheu K, Arinola Ganiyu O, Akiibinu Moses O
Immunology Unit, Department of Chemical Pathology, College of Medicine, University of Ibadan, Ago-Iwoye, Oyo State, Nigeria.
J Res Med Sci. 2013 Jan;18(1):27-30.
The effect of Human Immunodeficiency Virus (HIV) on the immune system is well documented however; its impact on the nutritional and immunological qualities of the breast milk is scarce.
Levels of some essential trace metals, albumin and antioxidant status in the plasma and breast milk of Nigerian HIV-infected lactating mothers were determined.
Essential trace metals and total antioxidant potential were measured using spectrophotometric method while albumin was measured using single radial immunodiffusion technique.
Only the mean plasma level of albumin in HIV infected lactating mothers (HIM) was significantly reduced when compared with HIV free lactating mothers (HFM) [9.39 (4.46) g/L vs 26.18 (18.43) g/L, P=0.000], others had no significant difference. The mean breast milk levels of total antioxidant potential (1776.82(564.26) μmolTE/L vs. 2384.67 (679.00) μmolTE/L, P = 0.0000), Cu [67.68 (5.04) μg/dL vs. 71.10 (5.45) μg/dL, P = 0.033] and Fe [66.21 (6.31) μg/dL vs. 71.20 (6.48) μg/dL, P = 0.011] were significantly reduced in HIM compared with HFM. No significant differences were observed in other parameters.
It could be concluded from this study that hypoalbuminemia is a feature of HIV-infected lactating mothers and that breast milk of HIM has low antioxidant capacity.
人类免疫缺陷病毒（HIV）对免疫系统的影响已有充分记录，然而，其对母乳营养和免疫特性的影响却鲜有研究。
测定尼日利亚感染HIV的哺乳期母亲血浆和母乳中某些必需微量元素、白蛋白水平及抗氧化状态。
采用分光光度法测定必需微量元素和总抗氧化能力，采用单向放射免疫扩散技术测定白蛋白。
与未感染HIV的哺乳期母亲（HFM）相比，感染HIV的哺乳期母亲（HIM）血浆白蛋白平均水平显著降低[9.39（4.46）g/L对26.18（18.43）g/L，P = 0.000]，其他指标无显著差异。与HFM相比，HIM母乳中总抗氧化能力平均水平（1776.82(564.26) μmolTE/L对2384.67 (679.00) μmolTE/L，P = 0.0000）、铜[67.68 (5.04) μg/dL对71.10 (5.45) μg/dL，P = 0.033]和铁[66.21 (6.31) μg/dL对71.20 (6.48) μg/dL，P = 0.011]显著降低。其他参数未观察到显著差异。
本研究可以得出结论，低白蛋白血症是感染HIV的哺乳期母亲的一个特征，且HIM的母乳抗氧化能力较低。
