Ghasemi-Mobarakeh Laleh, Prabhakaran Molamma P, Balasubramanian Preethi, Jin Guorui, Valipouri Afsaneh, Ramakrishna Seeram
Textile Department-Isfahan University of Technology, Isfahan, Iran.
J Nanosci Nanotechnol. 2013 Jul;13(7):4656-71. doi: 10.1166/jnn.2013.7186.
Regeneration of bone and cartilage tissues has been an important issue for biological repair in the field of regenerative medicine. The rapidly emerging field of tissue engineering holds great promise for repair and generation of functional bone and cartilage substitutes with a combination of biomaterials, cells, drugs and growth factors. Scaffolds play a pivotal role in tissue engineering as they mimic the natural extracellular matrix (ECM) and play an important role in guiding cell adhesion and proliferation, and maintaining the normal phenotype of the tissues. The use of tissue-engineered grafts based on scaffolds has found to be a more effective method than conventional implantations of autograft, allograft, xenograft. In recent years much attention has been given to electrospinning as a feasible and versatile technique for fabrication of nanofibrous scaffolds, with large surface area to volume ratio, high porosity, mechanical properties and physical dimension similar to the ECM of natural tissues. Extensive research has been carried out for fabrication polymeric nanofibrous substrates with incorporation of hydroxyapatite nanoparticles or bone morphogenetic protein molecules for efficient tissue repair. Here we review on the literature of electrospun nanofibrous scaffolds, their modifications, and advances aimed towards the rapid regeneration of bone and cartilage.
骨组织和软骨组织的再生一直是再生医学领域生物修复的重要课题。迅速兴起的组织工程领域，通过生物材料、细胞、药物和生长因子的组合，为功能性骨和软骨替代物的修复与生成带来了巨大希望。支架在组织工程中起着关键作用，因为它们模拟天然细胞外基质（ECM），在引导细胞黏附与增殖以及维持组织正常表型方面发挥重要作用。基于支架的组织工程移植物的应用已被证明是一种比传统的自体移植、异体移植和异种移植更有效的方法。近年来，静电纺丝作为一种可行且通用的制备纳米纤维支架的技术备受关注，其具有大的表面积与体积比、高孔隙率、与天然组织的ECM相似的机械性能和物理尺寸。为了实现高效的组织修复，人们已经开展了大量研究来制备掺入羟基磷灰石纳米颗粒或骨形态发生蛋白分子的聚合物纳米纤维基质。在此，我们综述了关于静电纺纳米纤维支架及其改性以及旨在实现骨和软骨快速再生的进展的文献。
