Montella A, Dessì A L
Istituto di Anatomia umana normale, Università di Sassari.
Boll Soc Ital Biol Sper. 1990 Apr;66(4):315-22.
The ontogenesis of the surface epithelium in the gastric mucosa was studied by means of light and electron microscopy in 41 human foetuses ranging from 7th to 12th week of gestational age. The results obtained can be summarized as follows: 1) At the 7th week the gastric mucosa shows a simple pseudostratified epithelium; the epithelial cells are undifferentiated and filled, with glycogen clusters. 2) From the 8th week the epithelial surface shows small depressions that become deeper in the mesenchyme making the first bud of the gastric foveolae. 3) At the 9-10th week the gastric foveolae are more developed. The cells of the gastric epithelium can be therefore separated in two populations: a) the cells of the foveolae; b) the cell of the mucosal surfaces. 4) At the 12th week the cells of the mucosal surface become, on the basis of their histochemical and ultrastructural characteristics, surface mucous cells. The morphological differentiation is testified mainly by the transposition of the nuclei in the basal parts of the cells and by the gradual substitution of the cytoplasmic glycogen by mucous granules.
利用光学显微镜和电子显微镜对41例孕龄在7至12周的人类胎儿胃黏膜表面上皮的个体发生进行了研究。所得结果总结如下：1）在第7周时，胃黏膜呈现简单的假复层上皮；上皮细胞未分化，充满糖原簇。2）从第8周开始，上皮表面出现小凹陷，这些凹陷在间充质中变得更深，形成胃小凹的第一个芽。3）在第9至10周时，胃小凹更加发达。因此，胃上皮细胞可分为两类：a）小凹细胞；b）黏膜表面细胞。4）在第12周时，根据其组织化学和超微结构特征，黏膜表面细胞成为表面黏液细胞。形态学分化主要通过细胞核向细胞基部的移位以及细胞质糖原逐渐被黏液颗粒取代来证明。
