Department of Health & Nutrition Sciences, Montclair State University, University Hall 4190, 1 Normal Avenue, Montclair, NJ 07043, USA.
Future Oncol. 2013 Aug;9(8):1097-103. doi: 10.2217/fon.13.108.
Many studies have supported the protective effects of broccoli and broccoli sprouts against cancer. The chemopreventive properties of sulforaphane, which is derived from the principal glucosinolate of broccoli and broccoli sprouts, have been extensively studied. Recent research into the effects of sulforaphane on cancer stem cells (CSCs) has drawn lots of interest. CSCs are suggested to be responsible for initiating and maintaining cancer, and to contribute to recurrence and drug resistance. A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-κB, SHH, epithelial-mesenchymal transition and Wnt/β-catenin pathways. Combination therapy with sulforaphane and chemotherapy in preclinical settings has shown promising results. In this article, we focus on the effects of sulforaphane on CSCs and self-renewal pathways, as well as giving a brief review of recent human studies using broccoli sprout preparations.
许多研究都支持西兰花和西兰花芽对癌症的保护作用。萝卜硫素是西兰花和西兰花芽中主要的硫代葡萄糖苷衍生而来，其化学预防特性已得到广泛研究。最近对萝卜硫素对癌症干细胞（CSC）的影响的研究引起了广泛关注。CSC 被认为是引发和维持癌症的原因，并导致癌症复发和耐药性。许多研究表明，萝卜硫素可能通过调节 NF-κB、SHH、上皮-间充质转化和 Wnt/β-catenin 通路来靶向不同类型癌症的 CSC。在临床前环境中，萝卜硫素与化疗的联合治疗显示出有前景的结果。在本文中，我们重点关注萝卜硫素对 CSC 和自我更新途径的影响，并简要回顾了最近使用西兰花芽制剂的人体研究。
