Patel S, O'Gorman P
J Clin Pathol. 1975 May;28(5):414-7. doi: 10.1136/jcp.28.5.414.
Serum gamma glutamyl transpeptidase (GGTP), isocitrate dehydrogenase (ICD), ornithine carbamoyl transferase (OCT), alanine aminotransferase (AlT), aspartate aminotransferase (AsT), and alkaline phosphatase (ALP) activities were assayed in 67 alcoholics and 40 drug dependent patients. Bilirubin, total protein, albumin, and globulin were also measured. GGTP elevation was observed in 48% of alcoholics and in 50% of drug dependents. The incidences of elevated levels of other enzymes were: ICD 39 and 38-7%; OCT 23-7 and 36-1%; AlT 30 and 33%; AsT 24-2 and 21-7%; ALP 10-4 and 5% respectively. Measurement of GGTP is thus more useful as a screening test for involvement of the liver in alcoholics and drug dependent patients than that of the other enzymes.
对67名酗酒者和40名药物依赖患者的血清γ-谷氨酰转肽酶（GGTP）、异柠檬酸脱氢酶（ICD）、鸟氨酸氨甲酰转移酶（OCT）、丙氨酸氨基转移酶（AlT）、天冬氨酸氨基转移酶（AsT）和碱性磷酸酶（ALP）活性进行了测定。还检测了胆红素、总蛋白、白蛋白和球蛋白。48%的酗酒者和50%的药物依赖患者出现GGTP升高。其他酶水平升高的发生率分别为：ICD为39%和38.7%；OCT为23.7%和36.1%；AlT为30%和33%；AsT为24.2%和21.7%；ALP为10.4%和5%。因此，对于筛查酗酒者和药物依赖患者肝脏受累情况，检测GGTP比检测其他酶更有用。
