JAMA Psychiatry. 2013 Sep;70(9):975-82. doi: 10.1001/jamapsychiatry.2013.382.
Autism spectrum disorder (ASD) is a brain-based pervasive developmental disorder, which-by growing consensus-is associated with abnormal organization of functional networks. Several previous studies of ASD have indicated atypical hemispheric asymmetries for language.
To examine the asymmetry of functional networks using a data-driven approach for a comprehensive investigation of hemispheric asymmetry in ASD.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study involved 24 children with ASD and 26 matched typically developing children at San Diego State University and the University of California, San Diego. Data from 10 children had to be excluded for excessive motion, resulting in final samples of 20 participants per group.
Asymmetry indices of functional networks identified from independent component analysis of resting-state functional magnetic resonance imaging data.
Temporal concatenation independent component analysis, performed separately in each group, showed significant group differences in asymmetry indices for 10 out of 17 functional networks. Without exception, these networks (visual, auditory, motor, executive, language, and attentional) showed atypical rightward asymmetry shifts in the ASD group.
Atypical rightward asymmetry may be a pervasive feature of functional brain organization in ASD, affecting sensorimotor, as well as higher cognitive, domains.
自闭症谱系障碍（ASD）是一种基于大脑的广泛发育障碍，越来越多的共识认为其与功能网络的异常组织有关。几项先前的 ASD 研究表明，语言存在非典型的半球不对称性。
使用数据驱动的方法来研究 ASD 中的半球不对称性，以全面研究功能网络的不对称性。
设计、环境和参与者：这项横断面研究涉及圣地亚哥州立大学和加利福尼亚大学圣地亚哥分校的 24 名 ASD 儿童和 26 名匹配的典型发育儿童。由于运动过多，有 10 名儿童的数据必须排除在外，最终每组有 20 名参与者。
从静息状态功能磁共振成像数据的独立成分分析中识别出功能网络的不对称指数。
在每个组中分别进行的时间串联独立成分分析显示，17 个功能网络中有 10 个的不对称指数存在显著的组间差异。无一例外，这些网络（视觉、听觉、运动、执行、语言和注意力）在 ASD 组中表现出非典型的右偏不对称性变化。
非典型的右偏可能是 ASD 中功能大脑组织的普遍特征，影响感觉运动和更高认知领域。
