Ergun Onur, Atlı Eray, Gulek Bozkurt, Ciftci Turkmen, Cil Barbaros, Vargel Ibrahim, Peynircioğlu Bora
Department of Radiology, Sincan State Hospital, Ankara, Turkey,
Surg Today. 2014 Jul;44(7):1232-41. doi: 10.1007/s00595-013-0680-8. Epub 2013 Aug 2.
The purpose of this study was to investigate the efficacy and safety of intraarterial transcatheter administration of polidocanol as an alternative treatment for peripheral arteriovenous malformations (AVMs).
The study comprised 10 patients (six males and four females) with a mean age of 28.8 years (range 8-52 years). All patients had trunk or extremity AVMs. Following the administration of general anesthesia or intravenous (IV) sedation, the patients underwent staged intraarterial polidocanol sclerotherapy with or without additional embolizations for their AVMs. The administration of polidocanol was executed by intraarterial infusion through a microcatheter or by direct percutaneous entry into the nidus under ultrasound guidance.
A total of 19 sessions were accomplished in 10 patients. Polidocanol was used alone in six of the 19 sessions. In 13 sessions, polidocanol was used in combination with another agent (including n-butyl cyanoacrylate (NBCA), lipiodol, and ethanol) and/or coils. In two sessions, polidocanol was administered percutaneously under ultrasound guidance directly into the nidus documented by arteriography. No major complications occurred.
Intraarterial transcatheter administration of polidocanol alone or in combination with other agents is a safe and effective alternative treatment for peripheral AVMs.
本研究旨在探讨经动脉导管注入聚多卡醇作为外周动静脉畸形（AVM）替代治疗方法的疗效和安全性。
本研究纳入10例患者（6例男性，4例女性），平均年龄28.8岁（范围8 - 52岁）。所有患者均患有躯干或四肢AVM。在全身麻醉或静脉镇静后，患者接受分期经动脉聚多卡醇硬化治疗，其AVM可联合或不联合额外的栓塞治疗。聚多卡醇通过微导管经动脉输注或在超声引导下直接经皮穿刺进入病灶进行给药。
10例患者共完成19次治疗。19次治疗中有6次单独使用聚多卡醇。在13次治疗中，聚多卡醇与其他药物（包括氰基丙烯酸正丁酯（NBCA）、碘油和乙醇）和/或弹簧圈联合使用。在2次治疗中，在超声引导下经皮将聚多卡醇直接注入经动脉造影证实的病灶内。未发生重大并发症。
经动脉导管单独或联合其他药物注入聚多卡醇是外周AVM一种安全有效的替代治疗方法。
