Department of Psychiatry, CB# 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7160, USA,
Arch Womens Ment Health. 2013 Dec;16(6):465-73. doi: 10.1007/s00737-013-0372-9. Epub 2013 Aug 1.
Perinatal depression (PND) is a common complication of pregnancy and postpartum associated with significant morbidity. We had three goals: (1) to explore the performance of a new lifetime version of the Edinburgh Postnatal Depression Scale (EPDS-Lifetime) to assess lifetime prevalence of PND; (2) to assess prevalence of lifetime PND in women with prior histories of major depressive episode (MDE); and (3) to evaluate risk factors for PND. Subjects were from the Netherlands Study of Depression and Anxiety (NESDA). The EPDS was modified by adding lifetime PND screening questions, assessing worst episode, and symptom timing of onset. Of 682 women with lifetime MDD and a live birth, 276 (40.4 %) had a positive EPDS score of ≥12 consistent with PND. Women with PND more often sought professional help (p < 0.001) and received treatment (p = 0.001). Independent risk indicators for PND included younger age, higher education, high neuroticism, childhood trauma, and sexual abuse. We found that two in five parous women with a history of MDD had lifetime PND and that the PND episodes were more severe than MDD occurring outside of the perinatal period. The EPDS-Lifetime shows promise as a tool for assessing lifetime histories of PND in clinical and research settings.
围产期抑郁症（PND）是妊娠和产后的常见并发症，与显著的发病率有关。我们有三个目标：（1）探索新的终身版爱丁堡产后抑郁量表（EPDS-Lifetime）在评估围产期抑郁症终身患病率方面的表现；（2）评估有既往重度抑郁发作（MDE）病史的女性中终身 PND 的患病率；（3）评估 PND 的风险因素。研究对象来自荷兰抑郁和焦虑研究（NESDA）。EPDS 通过添加终身 PND 筛查问题、评估最严重发作和症状开始时间进行了修改。在 682 名有终身 MDD 和活产的女性中，276 名（40.4%）的 EPDS 评分≥12，符合 PND。患有 PND 的女性更常寻求专业帮助（p<0.001）并接受治疗（p=0.001）。PND 的独立风险指标包括年龄较小、受教育程度较高、神经质较高、儿童时期创伤和性虐待。我们发现，有五分之二的有 MDD 病史的经产妇患有终身 PND，且 PND 发作比围产期以外的 MDD 更严重。EPDS-Lifetime 有望成为在临床和研究环境中评估 PND 终身史的工具。
