Saint Joseph's Regional Medical Center, 703 Main Street, X618, Paterson, NJ 07503, USA.
Curr Pain Headache Rep. 2013 Sep;17(9):360. doi: 10.1007/s11916-013-0360-9.
In the current classification of headache disorders, headache attributable to genetic disorders is not classified separately, rather as headache attributed to cranial or cervical vascular disorder. The classification thus implies that a vascular pathology causes headache in these genetic disorders. Unquestionably, migraine is one of the prominent presenting features of several genetic cerebral small vessel diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy, retinal vasculopathy with cerebral leukodystrophy, and hereditary infantile hemiparessis, retinal arteriolar tortuosity and leukoencephalopahty. Shared genetic features, increased susceptibility, and/or vascular endothelial dysfunction may play a role in pathogenesis of migraine. Common or overlapping pathways involving the responsible genes may provide insight regarding the pathophysiological mechanisms that can explain their comorbidity with migraine. This review focuses on clinical features of genetic vasculopathies. An independent category-migraine related to genetic disorders-should be considered to classify these disorders.
在当前的头痛障碍分类中，归因于遗传疾病的头痛并未单独分类，而是归类为归因于颅或颈血管障碍的头痛。因此，该分类意味着血管病理学在这些遗传疾病中引起头痛。毫无疑问，偏头痛是几种遗传性脑小血管疾病的突出表现之一，例如伴有皮质下梗死和白质脑病的脑常染色体显性动脉病、伴有脑白质营养不良的视网膜血管病变、遗传性婴儿偏瘫、视网膜小动脉迂曲和白质脑病。遗传特征、易感性增加和/或血管内皮功能障碍可能在偏头痛发病机制中起作用。涉及相关基因的常见或重叠途径可能有助于了解可以解释其与偏头痛并存的病理生理机制。这篇综述重点介绍了遗传血管病的临床特征。应该考虑将与遗传障碍相关的偏头痛作为一个独立的类别来对这些障碍进行分类。
