Department of Biomedical Engineering, Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 (USA).
Angew Chem Int Ed Engl. 2013 Sep 16;52(38):9936-9. doi: 10.1002/anie.201305510. Epub 2013 Jul 31.
Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.
已构建了在膜中不活跃的脂化光响应结构，这些结构将生物试剂（R，见方案）隔离到细胞器和细胞的膜中。当与膜结合时，生物试剂不易被其生物靶标处理。光解将生物试剂从其膜锚释放出来，从而使其具有生物活性。
