Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and the Department of Pharmacology, University of North Carolina,Chapel Hill, NC 27599 (USA).
Angew Chem Int Ed Engl. 2014 Jan 13;53(3):875-8. doi: 10.1002/anie.201308816. Epub 2013 Nov 27.
Although the corrin ring of vitamin B12 is unable to efficiently absorb light beyond 550 nm, it is shown that commercially available fluorophores can be used as antennas to capture long-wavelength light to promote scission of the Co-C bond at wavelengths up to 800 nm. The ability to control the molecular properties of bioactive species with long visible and near-IR light has implications for drug delivery, nanotechnology, and the spatiotemporal control of cellular behavior.
虽然维生素 B12 的咕啉环无法有效地吸收超过 550nm 的光，但研究表明，市售的荧光团可用作天线来捕获长波长的光，以促进 Co-C 键在长达 800nm 的波长下的断裂。利用长可见和近红外光控制生物活性物质的分子性质，对药物输送、纳米技术和细胞行为的时空控制具有重要意义。
