Pequito Manuel, Amory Hélène, de Moffarts Brieuc, Busoni Valeria, Serteyn Didier, Sandersen Charlotte
Equine Clinic, Faculty of Veterinary Medicine, Liège University, Belgium.
Can Vet J. 2013 Feb;54(2):150-6.
The effects of norepinephrine (NOR) infusion on hemodynamic alterations induced with sedative doses of acepromazine (ACP) were evaluated. Infusion of NOR at 1 μg/kg body weight (BW)/minute for 15 min was administered to 5 standing horses 45 min (T45) after intravenous injection of ACP at 0.1 mg/kg BW. Systolic arterial blood pressure (SAP) and hemodynamic parameters were evaluated on the median artery. Parameters were evaluated every 5 min from 45 to 65 min (T65) at 75 (T75), 90 (T90), and 105 (T105) minutes after ACP administration, and the vessel's surface (SURF), diameter (DIAM), circumference (CIRC), peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF) and resistivity index (RI) of the flow were calculated. Acepromazine induced hypotension and vasodilation with a significant rise in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a reduction in RI and SAP, which were significantly counteracted from T50 to T60 for EDV, VF, MV and RI, and to T65 for SAP, from T50 to T90 for CIRC and SURF and to T60 for DIAM. These findings demonstrate that a 1 μg/kg BW/minute NOR infusion can reverse ACP's vasodilatory effects, restoring hemodynamic parameters and blood pressure in horses.
评估了去甲肾上腺素（NOR）输注对镇静剂量乙酰丙嗪（ACP）诱导的血流动力学改变的影响。在5匹站立的马静脉注射0.1mg/kg体重的ACP 45分钟（T45）后，以1μg/kg体重/分钟的速度输注NOR 15分钟。在正中动脉上评估收缩期动脉血压（SAP）和血流动力学参数。在注射ACP后的45至65分钟（T65）、75分钟（T75）、90分钟（T90）和105分钟（T105），每隔5分钟评估一次参数，并计算血管的表面积（SURF）、直径（DIAM）、周长（CIRC）、收缩期峰值速度（PSV）、舒张末期速度（EDV）、平均速度（MV）、容积流量（VF）和血流阻力指数（RI）。乙酰丙嗪诱导低血压和血管舒张，SURF、DIAM、CIRC、PSV、EDV、MV和VF显著升高，RI和SAP降低，从T50至T60，EDV、VF、MV和RI，以及从T50至T65的SAP，从T50至T90的CIRC和SURF以及至T60的DIAM均受到显著抵消。这些发现表明，以1μg/kg体重/分钟的速度输注NOR可以逆转ACP的血管舒张作用，恢复马的血流动力学参数和血压。
