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本文引用的文献

1
Folate, vitamin B12, and homocysteine levels in South Asian women with growth-retarded fetuses.患有胎儿生长受限的南亚女性体内的叶酸、维生素B12和同型半胱氨酸水平
Acta Obstet Gynecol Scand. 2005 Nov;84(11):1055-61. doi: 10.1111/j.0001-6349.2005.00876.x.
2
Hyperhomocysteinemia, pregnancy complications, and the timing of investigation.高同型半胱氨酸血症、妊娠并发症及检查时机
Obstet Gynecol. 2004 Aug;104(2):336-43. doi: 10.1097/01.AOG.0000129955.47943.2a.
3
Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia.患有严重妊娠并发症和血栓形成倾向的女性胎盘的病理特征。
Obstet Gynecol. 2001 Dec;98(6):1041-4. doi: 10.1016/s0029-7844(01)01621-0.
4
Familial thrombophilia and the occurrence of fetal growth restriction.家族性血栓形成倾向与胎儿生长受限的发生
Haematologica. 2001 Apr;86(4):428-31.
5
Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta.易栓症：妊娠结局不良及胎盘血栓形成女性的一种发病机制。
J Matern Fetal Med. 1998 Nov-Dec;7(6):277-86. doi: 10.1002/(SICI)1520-6661(199811/12)7:6<277::AID-MFM5>3.0.CO;2-3.
6
Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction.补充叶酸和维生素B6对患有高同型半胱氨酸血症且有先兆子痫或胎儿生长受限病史的女性的影响。
Am J Obstet Gynecol. 1998 Jul;179(1):135-9. doi: 10.1016/s0002-9378(98)70263-7.

高同型半胱氨酸血症作为胎儿宫内生长受限的一个危险因素。

Hyperhomocysteinemia as a Risk Factor for IUGR.

作者信息

Pandey Kiran, Dubay Preeti, Bhagoliwal Ajay, Gupta Neena, Tyagi Geetika

机构信息

Department of Obstetrics & Gynaecology, G.S.V.M. Medical College, New Type IV/7, Kanpur, 208002 Uttar Pradesh India.

出版信息

J Obstet Gynaecol India. 2012 Aug;62(4):406-8. doi: 10.1007/s13224-012-0287-9. Epub 2012 Oct 16.

DOI:10.1007/s13224-012-0287-9
PMID:23904699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3500950/
Abstract

OBJECTIVE

To study the role of hyperhomocysteinemia in patients with intrauterine growth retardation.

METHOD

76 patients with intrauterine growth retardation were studied and compared with 50 controls which included pregnant patients without any pregnancy complications. Fasting Plasma homocysteine levels were measured and statistical analysis using tests of significance and logistic regression analysis was performed. Those in the study group were given homocysteine lowering agents for 6 wks and pregnancy outcome was studied.

RESULTS

57.8 % women in the study group were found to have hyperhomocysteinemia. Logistic Regression analysis shows an OR of 2.45 in favor of occurrence of IUGR if homocysteine levels are raised which is statistically significant. Mean plasma homocysteine levels decreased after treatment for 6 wks but this decrease in the case of placebo group is marginal whereas the decrease in the homocysteine levels the treatment group. This implies that treatment has a definitive role in lowering of plasma homocysteine levels.

CONCLUSION

The present study shows that hyperhomocysteinemia is associated with IUGR and should be identified as a risk factor as correction favors pregnancy outcome.

摘要

目的

研究高同型半胱氨酸血症在胎儿生长受限患者中的作用。

方法

对76例胎儿生长受限患者进行研究，并与50例对照者（包括无任何妊娠并发症的孕妇）进行比较。测量空腹血浆同型半胱氨酸水平，并进行显著性检验和逻辑回归分析的统计分析。研究组患者给予降低同型半胱氨酸药物6周，并研究妊娠结局。

结果

研究组中57.8%的女性被发现患有高同型半胱氨酸血症。逻辑回归分析显示，如果同型半胱氨酸水平升高，发生胎儿生长受限的优势比为2.45，具有统计学意义。治疗6周后，血浆同型半胱氨酸平均水平下降，但安慰剂组的下降幅度很小，而治疗组的同型半胱氨酸水平下降明显。这意味着治疗在降低血浆同型半胱氨酸水平方面具有决定性作用。

结论

本研究表明，高同型半胱氨酸血症与胎儿生长受限有关，应将其确定为一个危险因素，因为纠正该因素有利于妊娠结局。