Li T C, Dockery P, Rogers A W, Cooke I D
Department of Obstetrics & Gynaecology, University of Sheffield, Jessop Hospital for Women.
Br J Obstet Gynaecol. 1990 Jul;97(7):576-82. doi: 10.1111/j.1471-0528.1990.tb02543.x.
This study compared endometrial development in the luteal phase of women with unexplained infertility (n = 30) with that in women with normal fertility (n = 70) by the use of quantitative histological techniques (morphometric analysis) on endometrial specimens which were precisely timed from the luteinizing hormone surge. When overall endometrial development (histological dating) was considered, the proportion of women with unexplained infertility who had retarded endometrial development (20%) was found to be significantly higher than for women with normal fertility (3%) (P less than 0.01). When individual histological features were considered, women with unexplained infertility were found to have significant deviation from the normal range established from fertile women in only five of the 14 histological features measured. All of these five features related to the glandular but not to the stromal component of the endometrium; four of these five features are related to glandular secretory activity.
本研究通过对从促黄体生成素高峰开始精确计时获取的子宫内膜标本，运用定量组织学技术（形态计量分析），比较了不明原因不孕症女性（n = 30）与正常生育力女性（n = 70）黄体期的子宫内膜发育情况。当考虑整体子宫内膜发育（组织学分期）时，发现不明原因不孕症女性中子宫内膜发育迟缓的比例（20%）显著高于正常生育力女性（3%）（P < 0.01）。当考虑个体组织学特征时，在测量的14项组织学特征中，仅5项特征显示不明原因不孕症女性与正常生育女性所确立的正常范围存在显著偏差。这五项特征均与子宫内膜的腺体成分有关，而与间质成分无关；其中四项特征与腺体分泌活动有关。
