Li T C, Dockery P, Cooke I D
University of Sheffield, Jessop Hospital for Women, UK.
Hum Reprod. 1991 Mar;6(3):325-30. doi: 10.1093/oxfordjournals.humrep.a137333.
In this study, the prevalence of retarded endometrial development in the luteal phase of an infertile population (20/142 = 14%) was found to be significantly higher (P less than 0.05) than in that of a control, fertile population (3/68 = 4.4%). However, when the infertile subjects were subdivided into groups of different aetiology, it was found that women with endometriosis and unexplained infertility had a significantly higher prevalence of retarded endometrium (6/21 = 29%, 10/48 = 21% respectively; P less than 0.01 in both cases) than women with normal fertility; whereas the prevalence in women with tubal or male infertility (1/34 = 2.9% and 3/39 = 7.7%, respectively) was not significantly different from that in the fertile subjects. There were no significant differences in the progesterone profiles of the four groups of infertile subjects and the group of fertile subjects. Of the 15 cases of retarded endometrial development with known progesterone profile, two were associated with subnormal progesterone whereas the remaining 13 were associated with normal progesterone, the latter suggesting an abnormal response of the endometrium to a normal amount of progesterone. The findings suggest that further morphological study of the endometrium should be aimed at subjects whose infertility is unexplained or associated with endometriosis, in whom the prevalence of abnormal endometrium is increased.
在本研究中，发现不孕人群黄体期子宫内膜发育迟缓的发生率（20/142 = 14%）显著高于对照组有生育能力人群（3/68 = 4.4%）（P<0.05）。然而，当将不孕受试者按不同病因分组时，发现患有子宫内膜异位症和不明原因不孕的女性子宫内膜发育迟缓的发生率显著高于有正常生育能力的女性（分别为6/21 = 29%，10/48 = 21%；两种情况P均<0.01）；而输卵管性或男性因素不孕女性的发生率（分别为1/34 = 2.9%和3/39 = 7.7%）与有生育能力的受试者相比无显著差异。四组不孕受试者和有生育能力受试者组的孕酮水平无显著差异。在15例已知孕酮水平的子宫内膜发育迟缓病例中，2例与孕酮水平低于正常有关，其余13例与孕酮水平正常有关，后者提示子宫内膜对正常量孕酮反应异常。研究结果表明，子宫内膜的进一步形态学研究应针对不明原因不孕或与子宫内膜异位症相关的不孕患者，这些患者子宫内膜异常的发生率增加。
